Oncogenes Flashcards

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1
Q

BCR-ABL

A

Tyrosine kinase

CML
ALL

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2
Q

BCL2

A

Antiapotptotic molecule

Follicular and undifferentiated lymphomas

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3
Q

BRAF

A

Serine/threonine kinase

Melanoma
Non-Hodgkin lymphoma

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4
Q

c-kit

A

Cytokine receptor

Gastrointestinal stromal tumor (GIST)

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5
Q

c-myc

A

Transcription factor

Burkitt lymphoma

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6
Q

HER2/neu (c-erbB2)

A

Tyrosine kinase

Breast carcinoma
Ovarian carcinoma
Gastric carcinoma

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7
Q

L-myc

A

Transcription factor

Lung tumor

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8
Q

N-myc

A

Transcription factor

Neuroblastoma

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9
Q

RAS

A

GTPase

Colon cancer
Lung cancer
Pancreatic cancer

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10
Q

RET

A

Tyrosine kinase

MEN2A and 2B
Medullary thyroid cancer

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