Disease Conditions and Associated Neoplasms Flashcards

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1
Q

Acanthosis nigricans

A

Rare neoplastic indicator of visceral malignancy (more commonly associated with insulin resistance)

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2
Q

Barrett esophagus

A

Precursor to esophageal adenocarcinoma

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3
Q

Chronic atrophic gastritis, postsurgical gastric remnant

A

Predispose to gastric adenocarcinoma

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4
Q

Cirrhosis

A

Predisposes to hepatocellular carcinoma

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5
Q

Ulcerative colitis

A

Predisposes to colon adenocarcinom

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6
Q

Actinic keratosis

A

Precursor to squamous cell carcinoma of the skin

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7
Q

Dermato and polymyositis

A

Predispose to visceral malignancies, particulary genitourinary

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8
Q

Dysplastic nevus

A

Precursor to malignant melanoma

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9
Q

Multiple seborrheic keratoses

A

GI, breast, lung, and lymphoid malignancies

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10
Q

Paget disease of the bone

A

Predisposes to secondary osteosarcoma and fibrosarcoma

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11
Q

Plummer- Vinson syndrome

A

Predisposes to squamous cell carcinoma of the esophagus

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12
Q

Tuberous sclerosis

A

Often manifests with multiple hamartomatous (benign) tumors including giant cell astrocytomas, renal angiomyolipomas, cardiac rhabdomyiomas

Tumors may become malignant

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13
Q

Xeroderma pigmentosum

Albinism

A

Predispose to squamous cell carcinoma, basal cell carcinoma, melanoma

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14
Q

AIDS

A

Presidposes to aggressive lymphoma (non-Hodgkin) and Kaposi sarcoma

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15
Q

Autoimmune diseases (Hashimotos, SLE)

A

Predispose to lymphoma

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16
Q

Down syndrome

A

Predispose to acute lymphocytic leukemia

17
Q

Immunodeficiency

A

Predisposes to lymphoma, melanoma, renal cell carcinoma

18
Q

Li-Fraumeni syndrome

A

p53 mutation predisposes to various cancer types at a young age (sarcoma, breast, leukemia, adrenal gland)

19
Q

Radiation exposure

A

High risk of developing leukemia, sarcoma, papillary thyroid cancer, breast cancer