Tumor Suppressor Genes Flashcards
1
Q
APC
A
Colorectal cancer (associated with FAP)
2
Q
BRCA1
A
Breast & ovarian cancer
DNA repair protein
3
Q
BRCA2
A
Breast & ovarian cancer
DNA repair protein
4
Q
CPD4/SMAD4
A
Pancreatic cancer
DPC gene product
5
Q
DCC
A
Colon cancer
DCC gene product
6
Q
MEN
A
MEN type I
7
Q
NF1
A
Neurofibromatosis type 1
RAS GTPase activating protein (neurofibromin)
8
Q
NF2
A
Neurofibromatosis type 2
Merlin (schwannomin) protein
9
Q
p16
A
Melanoma
Cyclin-dependent kinase inhibitor 2A
10
Q
p53
A
Most human cancers, Li-Fraumeni syndrome
Transcription factor for p21, blocks G1 –> S phase
11
Q
PTEN
A
Breast cancer, prostate cancer, endometrial cancer
12
Q
Rb
A
Retinoblastoma, osteosarcoma
Inhibits E2F, blocks G1 –> S phase
13
Q
TSC1
A
Tuberous sclerosis
Hamartin protein
14
Q
TSC2
A
Tuberous sclerosis
Tuberin protein
15
Q
VHL
A
von Hippel-Lindau disease
Inhibits hypoxia inducible factor 1a
