G-protein-linked 2nd messengers Flashcards
1
Q
α1
G-protein class?
Major Functions?
A
α1
- G protein class: q
- Increased vascular smooth muscle contraction
- Increased pupillary dilator muscle contraction (mydriasis)
- Increased intestinal & bladder sphincter muscle contraction
2
Q
α2
G-protein class?
Major Functions?
A
α2
- G protein class: i
- Decreased sympathetic outflow
- Decreased insulin release
- Decreased lipolysis
- Increased platelet aggregation
3
Q
ß1
G-protein class?
Major Functions?
A
ß1
- G protein class: s
- Increased HR
- Increased contractility
- Increased renin release
- Increased lipolysis
4
Q
ß2
G-protein class?
Major Functions?
A
ß2
- G protein class: s
- Vasodilation, bronchodilation
- Increased HR
- Increased contractility
- Increased lipolysis
- Increased insulin release
- Decreased uterine tone (tocolysis)
- Ciliary muscle relaxation
- Increased aqueous humor production
5
Q
M1
G-protein class?
Major Functions?
A
M1
- G protein class: q
- CNS
- Enteric nervous system
6
Q
M2
G-protein class?
Major Functions?
A
M2
- G protein class: i
- Decreased HR
- Decreased contractility of atria
7
Q
M3
G-protein class?
Major Functions?
A
M3
- G protein class: q
- Increased exocrine gland secretions
- Increased gut peristalsis
- Increased bladder contraction
- Bronchoconstriction
- Increased pupillary sphincter muscle contraction (miosis)
- Ciliary muscle contraction (accomodation)
8
Q
D1
G protein class?
Major Functions?
A
D1
- G protein class: s
- Relaxes renal vascular smooth muscle
9
Q
D2
G-protein class?
Major Functions?
A
D2
- G protein class: i
- Modulates transmitter release, especially in the brain
10
Q
H1
G-protein class?
Major Functions?
A
H1
- G protein class: q
- Increased nasal & bronchial mucus production
- Increased vascular permeability
- Contraction of bronchioles
- Pruritis & pain
11
Q
H2
G-protein class?
Major Functions?
A
H2
- G protein class: s
- Increased gastric acid secretion
12
Q
V1
G-protein class?
Major Functions?
A
V1
- G protein class: q
- Increased vascular smooth muscle contraction
13
Q
V2
G-protein class?
Major Functions?
A
V2
- G protein class: s
- Increased H2O permeability & reabsorption in the collecting tubules of the kidney
14
Q
What is the pneumonic for Gq?
A
HAVe 1 M&M
- H1
- α1
- V1
- M1
- M3
15
Q
What is the pneumonic for Gi?
A
MAD 2’s
- M2
- α2
- D2
