Tumor Suppressor Genes

Question 0

BRCA1/BRCA2

Answer 0

Tumor: breast and ovarian

Gene product: DNA repair protein

Question 1

APC

Answer 1

Tumor: colorectal cancer

Gene product: none

Question 2

DCC

Answer 2

Tumor: colon

Gene product: DCC

Question 3

DPC4/SMAD4

Answer 3

Tumor: Pancreatic cancer

Gene product: DPC

Question 4

MEN1

Answer 4

Tumor: MEN1

Gene product: Menin

Question 5

NF1

Answer 5

Tumor: Neurofibromatosis type 1

Gene product: RAS GTPase activating protein (neurofibromin)

Question 6

NF2

Answer 6

Tumor: Neurofibromatosis type 2

Gene product: Merlin (Schwannomin) protein

Question 7

P16

Answer 7

Tumor: Melanoma

Gene product: Cyclin-dependent kinase inhibitor 2A

Question 8

P53

Answer 8

Tumor: most human cancers, Li-Fraumeni Syndrome

Gene product: Transcription Factor for p21, blocks G1~>S phase

Question 9

PTEN

Answer 9

Tumor: breast cancer, prostate cancer, endometrial cancer

Gene product: none

Question 10

Rb

Answer 10

Tumor: Retinoblastoma, osteosarcoma

Gene product: Inhibits E2F; blocks G1~> S phase

Question 11

TSC1

Answer 11

Tumor: Tuberous Sclerosis

Gene product: Hamartin Protein

Question 12

TSC2

Answer 12

Tumor: Tuberous Sclerosis

Gene product: Tuberin Protein

Question 13

VHL

Answer 13

Tumor: Von Hippel-Lindau disease, renal cell carcinoma

Gene product: inhibits inducible factor la

Question 14

WT1/WT2

Answer 14

Tumor: Wilms Tumor (nephroblastoma)

Gene product: