Tumor Markers Flashcards
T/ F. IHC detects stages of cancer
True
Tumor markers are found in
Tissues
Marker for Epithelial Tissue cells
Keratin
Marker for Epithelial Tissue cells; used as diagnosis marker for CARCINOMA
Keratin
Epithelial Tumor Marker for LUNGS, OVARY, UTERUS cancer
CK 7
Epithelial Tumor Marker for Stomach and COLON
CK 20
T/F. All carcinoma are tested positive for CK
FALSE
An epithelial tissue marker that is useful for detecting SITE of tumor
Epithelial Membrane Antigen
Epithelial Tissue Marker; used for diagnosis of ADENOCARCINOMA + BLK (Breast, Lung, Kidney)
Epithelial Membrane Antigen
An oncofetal antigen
Carcinoembryonic Antigen (CEA)
Differentiates Adenocarcinoma from mesothelioma
Carcinoembryonic Antigen (CEA)
Cancers in the ______ is associated with CEA
CCBP
Colon
Cervix
Breast
Pancreas
Cancer of epithelial tissue and glands
Adenocarcinoma
Differentiates LUNG ADENOCARCINOMA and MESOTHELIOMA
Thyroid Transcription Factor - 1 (TTF-1)
Found in all thyroid neoplasm
TTF-1
Tumor marker for GIT cancer
CEA
Highly Specific antigen for prostate
Prostate Specific Antigen
Tumor marker for Prostate, Pancreas, and Salivary tumor
Prostate Specific Antigen (PSA)
Associated with Prostate infection
Prostate Specific Antigen (PSA)
Tumor marker seen in Breast Epithelial cells
Estrogen Progesterone Receptor
T/F.
ER/PR is seen in MYOEPITHELIAL CELLS
false
Purpose of ER/PR
- Prognosis and treatment for breast cancer
- Identification of Metastatic Breast Carcinoma
Patient with Breast cancer currently under medication has a (+) ER/PR test =
good prognosis
diagnosis marker for cancer of SKELETAL, CARDIAC, AND SMOOTH MUSCLE CELL
Actin
Normally seen in mesenchymal cells
Vimentin
Tumor marker for
1. Sarcoma
2. Melanoma
3. Leukemia
4. Seminoma
5. Schwannomas
Vimentin
Highly specific for Myogenic tumor
Desmin
Confirm diagnosis for ASTROCYTOMA
Glial Fibrillary Acidic Protein (GFAP)
Produced by Placental Syncytiotrophoblast
Human Chorionic Gonadotrophin (HCG)
Diagnostic Choriocarcinoma
HCG
Best screening marker for LYMPHOMA
CD45
Tumor marker for:
Embryonic Marker
Teratoma
Hepatocellular carcinoma
Alpha Feto Protein (AFP)
Two most common marker for assessing proliferation of tumor
Ki + MIB-1