Tuesday, 4-26-CIS ANS Pharmacology (Kruse)

Question 1

Stimulation of beta-2 receptors has what affect on smooth muscle?

Answer 1

Relax–> vasodilate

Question 2

Stimulation of muscarinic receptors has what affect on smooth muscle?

Answer 2

Contract smooth muscle (different IC signal than alpha1)

Question 3

Ach and muscarinic agonists given IV has what affect on vasculature?

Answer 3

Vasodilation d/t release of NO

Question 4

Is salivation and lacrimation PS or Symp?

Answer 4

PS

Question 5

Are urination and defection PS or Symp?

Answer 5

PS

Question 6

Is increased secretion and motility PS or Symp?

Answer 6

PS

Question 7

Is decreased elimination of urine PS or symp?

Answer 7

Symp

Question 8

Relaxation of trigone and urinary sphincter is due to __ activity

Answer 8

PS

Question 9

How does activation of mAChR’s cause trigone and sphincter relaxation?

Answer 9

Produces EDRF (AKA NO) –> stimulation of NO release can occur from Ach, vasoactive products, and physical stimuli

Question 10

Contraction of tracheal and bronchial smooth muscle is d/t __ activity

Answer 10

PS –> M2 and M3 receptors

Question 11

The use of a selective beta-blocker in a patient with a pheochromocytoma will result in symptoms of ___

Answer 11

Unopposed alpha stimulation (i.e., vasoconstriction)

Question 12

What are symptoms associated with organophosphate inhibitor toxicity?

Answer 12

SLUDGE-Salivation, Lacrimation, Defecation, GI pain and gas, Emesis

GI symptoms occur 1st
Percutaneous absorption: localized sweating and muscle fasciculations

Question 13

What tx is appropriate for AChE (organophosphate) inhibitor toxicity?

Answer 13

Cholinesterase generators –> atropine, oxime, benzodiazepine to alleviate convulsions

Question 14

Stimulation of alpha-1 receptors has what affect on all smooth muscle? Vascular smooth muscle? Glandular smooth muscle?

Answer 14

Stimulate contraction of all smooth muscle
Vasoconstriction of vascular smooth muscle
Secretion from glandular smooth muscle