Tuberculosis

Question 1

what 4 abx are used in the inital phase of TB? RIPE

Answer 1

rifampicin
isoniazid
pyrazinamide
ethambutol

Question 2

how long is the initial phase of treatment?

Answer 2

2 months

Question 3

what 2 abx are used in the continuation phase?
how long is the continuation phase?

Answer 3

rifampicin and isoniazid

4 months

Question 4

what abx are used for latent TB and how long is the treatment?

Answer 4

3 months of rifamipicin + isoniazid
or 6 months of isoniazid

Question 5

what b vitamin is prescribed alongside TB treatment?
what is the reason for this?

Answer 5

B6 - pyridoxine
due to peripheral neuropathy

Question 6

what are the counselling points for rifampicin?

Answer 6

1. discolours soft contact lenses and bodily fluids orange-red
2. enzyme inducer therefore CPY450 interactions

Question 7

what are the counselling points for isoniazid?

Answer 7

1. peripheral neuropathy - given prophylactic pyridoxine
2. enzyme inhibitor so CYP interactions

Question 8

what should you counsel patients for signs of in pyrazinamide?

Answer 8

hepatotoxicty (abdo pain, dark urine, N&V)

Question 9

what are the counselling points for ethambutol ?

Answer 9

visual impairment/ocular toxicity