Fungal Infections Flashcards
what is voriconazole used to treat?
aspergillosis
what is amphotericin B used to treat?
cryptococcosis
what are the treatment options for vaginal thrush?
clotrimazole or fluconazole
what are the treatment options for oral thrush?
nystatin, miconazole, fluconazole
what antifungal is used to treat resistant thrush ?
itraconzaole
what are skin and nail infections treated with?
topical therapy
system - itraconazole, terbinafine
what is used to treat ring worm?
antifungal cream or terbinafine
how often do you treat a fungal nail with a amorolfine lacquer?
when do you need to refer someone with a fungal nail to GP?
- once weekly for up to 1 year
- refer to GP if under 18, more than 2 nails affected, diabetic, pregnant/breastfeeding
what are the 2 generic risks of antifungals?
which antifungal has the highest and lowest risk?
QT prolongation
and hepatotoxicty
lowest risk = fluconazole, highest in ketokonazole
can itraconzaole be taken with carbonated drinks?
yes - improves bioavailability
what should you do if someone on ketaconazole comes in with dark urine/N&V/abdo pain?
suspend treatment immediately, could be sign on hepatotoxicity
is ketoconazole an oral formulation?
no - been suspended, usually just in shampoo/topical
what antifungal can cause phototoxicty?
voriconazole
what 3 things do you need to consider in someone prescribed amphotericin B?
- caution in renal failure
- anaphylaxis risk - test dose with 30mins observation
- maintain same formulation between conventional, liposomal and lipid complex formulations (serious harm and fatal overdoses have occurred)
what prophylactic medication should you have on standby for someone being treated with amphotericin B?
antipyretics or hydrocortisone in patients with previous reactions
