TTR Flashcards
lowenstein-jensen
media used to culture m. tuberculosis 18-24h doubling time
HIV associated TB
m. avium-intracellulare complex(MAC) disseminated in HIV+ pt population
describe empiric therapy for staphylococcal infections
what are good empiric outpatient therapies?
if pt. is sick(bacteremia/pneumonia)-
- vancomyicn
- daptomycin
- linezolid
- ceftaroline
if pt. is not “sick”(outpatient skin/soft tissue) -
- clindamycin
- TMP/SMX
- doxycycline
- linezolid
most common species of enterococci how do their treatments differ?
E. faecalis - ampicillin/penicillin are drugs of choice; use ampicillin AND aminoglycoside for endocarditis
E. faecium - vancomycin is drug of choice; resistant to ampicillin; use vancomycin AND aminoglycoside for endocarditis
CN palsy
HA
fever
malaise
cardiovascular dysfunciton
arthritis
bug?
burellia burgdorferi
lyme disease
disseminated rash(soles, palms)
LAD
granulomatous lesions
AMS
treatment?
treponema pallidum infection
penicillin, doxycycline
ceftriaxone if brain is involved
prolly would use ceftriaxone w/AMS
lyme disease treatment
doxycycline
if contraindicated: amoxicilin, cefuroxime
ceftriaxone for disseminated(late)
conjunctival suffusion
fevers
myalgia
vomiting
diarrhea
treatment?
this is leptospirosis biphasic disease
treat w/supportive fluids and penicillin, doxy, or ceftriaxone(same as syphillus)
when to use abx with diarrhea
- c. diff(metro or vanc)
- shigellosis - based on susceptibility; clinda good
- campylobacter if early - ciprofloxacin
- v. cholerae - doxy, azithro, cipro [reduces severity after worst has passed]
- traveler’s - give em cipro or rifaximin
camps call-her different travel gels
when do you need a culture for diarrhea?
immunocompromised
outbreaks
dysentery
cholera
>24hr and WBC in stool
treatment for bacillus anthracus
COMBOOOOOOO
fluoroquinolone + clindamycin or rifampin + other agent
post exposure treatments: oral cipro or doxy or amoxi right away
assocaited with rabbit skinning
low infectious dose
GN rod
BT list
treatment?
francisella tularensis
aminoglycosides, fluoroquinolones, tetracyclines work
GP rod is found in LP of neonate
what is bacterial likely resistant to?
treatment?
this is listeria monocytogenes
resistant to cephalosporins and vancomycin
treat with penicillin, ampicillin, TMP-SMX
****gotta add an ampicillin when neonates have meningitis
leading cause of meningitis in immunocompromised
listeria monocytogenes
predominantly males
increased risk with liver disease
causes: chills, fever, prostration, nec fasc
associated with seawater/seafood
treatment?
vibrio vulnificus
aggressive treatment: debridement, tetracycline+cipro/ceftaxomine
presentation for/treatment of aeromonas spp.
disease of wound infection
cellulitis related to water/soil
bacteremia
can cause diarrheal disease
treat w/ TMP-SMX, fluoroquinolones, aminoglycosides
vesicoureteral reflux
pediatric UTI complication
use voiding cystourethrography to detect abnormalities
scarring, hydronephrosis
has LPS with NO endotoxin activity
which bacteria?
bacteroides fragilis!
GN anaerobe
name the “regal” GN coccobacilli that is one of the common causes of infectious arthritis in children
kingella kingae
bacteria w/ a type IV pilus co-expressed w/its toxin
- v. cholerae*
toxin co-regulated pilus
both activated by a ‘global regulator’
leading cause of seafood-associated gastroenteritis
v. parahaemolyticus
Watery, self-limited diarrhea, w/cramps, NV; sometimes bloody
when do you prescribe abx for an asymptomatic bacteriuria?
pregos screened positive in 1st trimester
1st line UTI drugs
2nd line UTI drugs
1st line: nitrofurantoin, fosfomycin or TMP-SMX
2nd line: fluoroquinolones
Try not to use a drug they’ve had in the past 3-6 mo.
what are the SIRS criteria
temp <36 or >38
puls >90
RR >20
WBC <4000 or >12000 or >10% bands
treatment for uncomplicated gonococcal infection
treatment for COMPLICATED?
uncomplicated: ceftriaxone(GC)
ALWAYS COTREAT FOR CHLAMYDIA
add on azithromycin(CHL)
complicated: ceftriaxone(GC) + doxycycline(CHL)
Listeria Monocytogenes pathogenesis and virulence factor for each step
- Invades cell(internalin, inlB)
- Escapes phagosome(lysteriolysin)
- Usurps actin(ActA)
- Spreads cell-to-cell(phospholipases)
early infection, acquired in utero, involving large disseminated micro-abscesses and high mortality
name? bug?
granulomatosis infantisepticum
neonatal listeriosis via listeria monocytogenes
