Trypanosoma cruzi Flashcards
Does it have zoonotic potential?
Yes, In the Americas
DH
**Dogs, opossums, rats, armadillos, mice, squirrels, fox, raccoon
IH
Insect vectors, Triatomine insect (cone nose bug, kissing bug)
How does the organism get into the host?
Bite wound or mucous membrane
Trypomastigotes enter vert. host cell (macrophages and others, mycocardiocytes)–> amastigotes and then what happens? (3 events!)
1- replication (binary fission)
2- differentiate into trypomastigotes
3- circulate and invade new cells (divide more) OOORRR lie dormant as amastigotes
Trypomastigote and _____ have a vert. host whereas _______ has an insect host only.
amastigote; epimastigote
Infective stage for DH:
Trypomastigote
Site for infection for trypomastigotes-
Site of infection for amastigotes-
blood; cardiac tissue
Route of infection
insect vector ingests trypomastigotes from blood meal
route of infection for vert. host-
Insect vector, transplacental or blood
Another route of infection possible is _____, other examples of routes of transmission include…
transplacental
other examples: blood transfusion, needles, biting, organ transplant, tattooing foxhounds, etc..
PPP
5-42 days
Clinical signs in dogs:
- Asymp.-** Chaga’s disease**
- Chronic- **congestive heart failure!!!*
- Acute, fever, anorexia, diarrhea, lethargy, enlarged spleen, liver and lymph nodes, cardiac dysfunction
- Latent
Clinical signs in Humans:
-Chaga’s disease
-Acute- anemia, CNS, muscle/bone pain, heart muscle damage
-Chronic- CNS disorders/ dementia, heart failure
-Transplacental infections- heart problems later on
Acute more in kids and chronic more in adults
Diagnosis
blood smear (trypomastigotes) and histo (cardiac tissue) for amastigotes
