Trimester 3 Exam Flashcards
Mutations
changes in the genetic code; occurs during replication
Germ cell mutation:
May be…
Does not affect…
Going to affect gametes (occurs during meiosis)
Passed on to offspring (if used to produce offspring)
The parent individual in which it occurs
Somatic-Cell Mutation:
Is not…
But an individual may inherit…
Affects…
Affects the body cells and occurs during mitosis
passed on to offspring
inherit genetic susceptibility
the individual in which the mutation occurs
Gene Mutations: Point Mutations: Substitution: May still code for... May also code for... Which changes the proteins and may... Ex.
Changes in a single gene or a series of related genes
change any single base/nucleotide
one nucleotide in a codon is replaced by different nucleotide
the same amino acid
a different amino acid
change the function and shape of the protein
sickle cell disease
Frame-Shift Mutations: the arrangement of nucleotide sequence into __________ is ___________ ; therefore each ________________ is changed from that point on
Deletion:
Insertion:
Codons; rearranged; amino acids
One nucleotide is removed
One nucleotide is added
Nondisjunction:
Resulting in one gamete receiving…
Ex.
The failure of homologous pairs of chromosomes to separate
An extra chromosome and one gamete lacking a chromosome
Down syndrome; Trisomy 21; Turners syndrome
Cancer: Tumor: Benign: Malignant: Metastasis:
Abnormal alliteration of cells resulting from uncontrolled an abnormal cell division
Massive abnormal cells that do not spread to other tissue
Uncontrolled dividing cells that invade and destroy healthy tissue
Movement of cancer to other parts of the body
Mutation may occur in genes that produce… Presence of oncogene: Carcinogenic: a. b. c.
Regulatory proteins that controlled the events of cell division
Gene that can cause cancer; from mutation, may be inherited may/may not be turned on
Cancer-causing agent
Chemicals - tobacco products (smoke/chew); asbestos; benzene; red dye
Radiation - x-rays; UV sun
Intense Heat
Pedigree analysis/chart:
Generally follows the…
Illustration that shows the relationship with any family in the passing of genetics
Recessive traits
Contrast Types of Mutations (know them)
Germ cell; somatic cell; Gene; point; frameshift on deletion; insertion; substitution; and nondisjunction
Be able to contrast the terms associated with cancer
Tumor: Abnormal alliteration of cells resulting from uncontrolled an abnormal cell division
Benign: Massive abnormal cells that do not spread to other tissue
Malignant:Uncontrolled dividing cells that invade and destroy healthy tissue
Metastasis: Movement of cancer to other parts of the body
Explain how a frameshift mutation would occur and why the effects can be so damaging.
Frame-Shift Mutations: the arrangement of nucleotide sequence into __________ (codon) is ___________(rearranged) ; therefore each ________________ (a.a.) is changed from that point on
Deletion: one nucleotide is removed
Insertion: one nucleotide is added
Because it changes the structure of amino acids in the function which results in so doing the wrong function due to the wrong structure because of the frameshift losing its importance
Structure of DNA Chemical Compostion- 1. 2. 3. a. Purines: b. Pyrimidines:
P.A. Levine
- Sugar Deoxiribose
- Phosphate Group
- Nitrogenous Base
a. Purines: Adenine & Guanine - both have two carbon and nitrogen rings
b. Pyrimadines: Thymine & cytosine - both have one carbon and nitrogen ring
Relative Quantities of Bases-
The amount of…
The amount of…
Therefore the charger rule states that…
Chargaff
A=T
G=C
Adenine pairs up with Thymine and Guanine pairs up with Cytosine
The shape of the DNA molecule-
Instrument used:
Determined the shape to be:
The images indicate that 2 strands of nucleotides exist, therefore:
Wilkins and Fraklin
X-Ray Photographs of DNA crystals
Helix
DNA is often called the double helix
The 2 strand/chains create a backbone and are composed of…
These nucleotides are held together by…
Alternating phosphate and sugar Deoxiribose
Covalently bonded relatively strong
The 2 strands or chains are held in the middle by…
These weak bonds allow…
Hydrogen bonds relatively weak
Separation of the chains for replication and transcription
Complementary base pairs
a.
b.
A w/ T 2 hydrogen bonds
G w/ C 3 hydrogen bonds
Essential nature of DNA structure to the genetic instructions:
Are dependent upon the exact sequence of bases on each nucleotide chain
Replication:
Why is replication essential?
In what part of the cycle does this occur?
The process of copying DNA for cell division and occurs in the nucleus of the cell
So that every new cell has a complete set of Genetic instructions
S phase of interface
Sequence of the steps 1. Separation of the two nucleotide chains at the replication origin. Replication Fork: Helicases: How?
The point at which two chains separate
Specific enzymes that separate the nucleotide chains
By breaking hydrogen bonds between base pairs
Action of DNA Polymerase: specific ___________ that binds to the…
Proofreading occurs by…
Enzyme; original/parent strand and assists in matching the new nucleotide chain
DNA Polymerase
Gene:
Sequence of DNA that codes for a protein and thus determines a trait.
RNA ( )
General role and significance of RNA
Location of genetic instructions (______):
Therefore the role of RNA is responsible for the…
Ex.
Ribose/Ribo nucleic acid
DNA; nucleus
Ribosomes in the cytoplasm (ER)
Movement of the genetic instructions from the nucleus to the ribosomes
Original blueprint DNA copies in the field RNA
Strands of RNA, sequence of... Differences between DNA and RNA a. b. c.
Nucleotides consisting of phosphate, sugar, and base
RNA is single-stranded while DNA is double-stranded
Sugar in RNA is ribose and DNA it is Deoxiribose
RNA contains base Uracil instead of Thymine
Types of RNA:
a.
b.
c.
Messenger RNA acquired the genetic instructions for protein for DNA and carries it to the ribosomes
Ribosomal RNA the forms 2 subunits to create ribosomes globular instructions
Transfer RNA uniquely structured RNA (hairpin)that binds 2 specific amino acids and transfers to the ribosomes
Transcription:
Takes place in the nucleus
Process by which specific genetic instructions for a protein is copied from DNA to messenger RNA
RNA polymerase primary transcription enzyme that…
Synthesizes makes messenger RNA
Protein Synthesis:
Significance of proteins amount and kind of proteins determine…
Therefore proteins carry out the…
Assembling/building proteins
The structure and function of cells
Genetic instructions of DNA
The genetic code:
The correlation exists between the nucleotide sequence from DNA to the nucleotides in mRNA leading to the amino acid sequence
Codon:
Maximum #
Group of 3 mRNA nucleotides that code for a specific animo acid
64
Translation:
Process begins by mRNA…
Amino acids in the ________ are transported by…
Possesses the __________:
Sequence of three…
Possesses a specialized region for attachment of a…
Process of assembling polypeptides/proteins from info covered by the mRNA (in ribosomes)
Leaving nucleus and going to the ribosomes
Cytoplasm; transfer RNA anticodon; nucleotides complementary to codon of mRNA