Tricyclics Flashcards

1
Q

What was the first antidepressants used for OCD?

A

Tricyclic clomipramine (brand name Anafrani)

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2
Q

What do Tricylics do?

A

They block the transporter mechanism that re-absorbs both serotonin and noradrenaline into the pre-synaptic cell after it has been fired

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3
Q

What is the benefit of tricyclics?

A

More transmitters are left in the synapse which prolong their activity

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4
Q

What is an advantage of tricyclics?

A

they can target more than one neurotransmitter

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5
Q

Name a disadvantage of tricylics?

A

The side effects are greater so they are used as a second-line treatment for patients when SSRI’s are not effective

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