Trematodes sukka Flashcards

1
Q
Typical features of Trematodes:
body shape: \_\_\_\_\_\_\_\_
segmented?: \_\_\_\_\_\_\_\_
body cavity?: \_\_\_\_\_\_\_\_
GI Tract:: \_\_\_\_\_\_\_\_
Separate sexes?: \_\_\_\_\_\_\_\_
All parasitic?: \_\_\_\_\_\_\_\_
A
body shape:  Flat/oval or leaf like
segmented?: No
body cavity?: No
GI Tract:: Yes, no anus
Separate sexes?: No except a few species
All parasitic?: Yes
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2
Q

All flukes of domestic animals are ____

A

digeneans

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3
Q

What is characteristic about Digenea life cycles?

A

Require one or more IH
#1 usually a mollusk
alternate asexual and sexual stages

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4
Q

General characteristics of digenean trematodes: body

A

body is flattened dorso ventrally
non segmented
leaf like shape
vary in size

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5
Q

General characteristics of digenean trematodes: external covering

A

Tegument
Syncytium- lacks ditinct cell boundaries
metabolically active (absorption/secretion)
may contain microvilli, spines, etc

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6
Q

T/F trematodes are coelomate organisms

A

FALSE- they are acoelmate- lack body cavity/coelom

organs are suspended in paranchyma

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7
Q

T/F in general the body part of the trematode responsible for absorption/secretion, the tegument, is located underneath the muscle layer

A

FALSE, muscle layer is under the tegument, it provides sluggish locomotion

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8
Q

How many suckers does the typical trematode have, where are they located?

A

Two;
anterior= oral sucker
ventral= acetabulum

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9
Q

T/F in genreal the mouth opening of trematodes is located within the oral sucker

A

FALSE located within the anterior sucker

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10
Q

T/F in general tematodes do not have teeth/lips

A

True

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11
Q

What are the 3 parts of teh typical trematodes digestive tract?

A

muscular pharynx, esophagus, blind gut/cecum

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12
Q

Since they dont have a b-hole… what happens to ingested food

A

cecal contents are regurgitated “Fluke Puke”

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13
Q

What is important about the typical characteristics of the Repro tract of tematodes?

A

Hermaphroditic

morphology of uterus, ovaries, testis of diagnostic value

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14
Q

How are trematode eggs detected?

A

Via sedimentation

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15
Q

What may be added to fecal sedimentation analysis for trematodes?

A

methylene blue

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16
Q

What are the 7 stages of the general life cycle of trematodes?

A
Adult
Egg- (developing embryo enclosed by shell, usually has operculum)
Miracidium
Sporocysts
Rediae
Cercariae
Metacercariae
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17
Q

What is a miracidium?

A

ciliated free swimming larvaa; enters snail intermediate host

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18
Q

T/F The sporocyst stage is essential for the development of the GI tract of trematodes

A

FALSE it doesnt have a GI tract

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19
Q

T/F The rediae stage is essential for the development of the GI tract of trematodes

A

TRUE-ish this is the stage where the rudimentary digestive tract develops

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20
Q

____ is the stage at which the trematode leaves the snail

A

cercadiae

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21
Q

____ is the stage w/in the 2nd IH or encysted on vegetation

A

metacercariae

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22
Q

____ is the infective stage of the trematode life cycle

A

metacercariae

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23
Q

How do companion animals typically acwuire Digenea trematodes?

A

acquired by eating fish, reptiles, amphibians, crustacians

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24
Q

What are the common digenea worms we learned for companion animals and the species they infect?

A
Nanophyteus salmincola (dog)
Platynosomum fastosum (cat)
Alaria spp (Dog/cat)
Paragonimus kellicotti (Dog)
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25
Q

How do RMTs typically acquire digenea trematodes?

A

acquired by eating metacercariae on vegetatiojn or ants

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26
Q

What are the common digenea worms we learned for RMTs and the species they infect?

A

Fasciola hepatica (Cattle>sm RMT)
Fascioloides magna (Deer, domestic RMT accidental)
Dicrocoelium dendriticum (Sheep>dom RMT, cervids)
Paramphistomum (Cattle>sm RMT)
Cotylophorum (sm RMT>Cattle)

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27
Q

What digenean trematode is known for infecting ants?

A

Dicrocoelium

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28
Q

this fluke’s real significance is that it is a vector for 2 rickettsial diseases

A

Nanophyetus salmoncida

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29
Q

What are the definitive and IH of N. salmoncida?

A

DH fish eating mammals, primarily raccons and spotted skunk, canines

IH 1 is snails that inhabit fresh/brackish water on coasts of WA, OR, CA

IH2 salmonid fishes

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30
Q

Why do we only see infections of Nanophyetus salmoncida in Pacific Northwest?

A

Only place that has BOTH intermediate hosts available

snail distribution is the major factor

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31
Q

outline the life cycle of Nanophyetus salmoncida

A

Adults pass eggs in feces
Miracidium develp in egg in environment in 3 mo

Miracidium hatches, penetrates snail, undergoes asexual reprod -> cercaia

Cercaira exit snail, penetrate fish, encyst as metacercaria in tissues

DH eats metacercaria in fish; can live 5 years, infective for several mo at low temp

Metacercariae excyst from fish tissue in DH attach to SI mucosa and mature to adults

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32
Q

What are the typical ckinical signs of N. salmoncida infection?

A

can cause superficial enteritis and possibly a hemorrhagic enteritis

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33
Q

What are the 2 rickettsial diseases associated with Nanophyetus salmoncida? which is more deadly?

A

“Salmon poisoning”- more deadly

Elokomin fluke fever

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34
Q

What is salmon poisoning/clin signs?

A

Neorickettsia helminthoeca

ONLY IN CANIDS
sudden onset, incubation 5-7

anorexia/high fever

purulent ocular discharge

vomiting, profuse, +/- hemorrhagic diarrhea

enlarged lymphnodes

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35
Q

What is the prognosis of “salmonoid poisoning”

A

60-90% mortality if untreated in 5-7 days

survivors immune

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36
Q

What causes Elokomin fluke fever, what are the clinical signs of it?

A

another strain Neorickettsia hemlinthoeca

clinical signs occur in a broader host range (not canids), high morbity, low mortality

signs similar to salmoidm but not as severe

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37
Q

What are the diagnosis and treatment of the rickettsial diseases?

A

Diagnosis:
fluke eggs in feces supportative evidence
detect rickettsia in lymph node aspirate

Tx
for both:
oxytetracyline IV
other tetracyclines, sulphonamides, penicillins

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38
Q

What species are infected with Alaria spp?

A

Several canids, felids, and mink

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39
Q

What are the IH hosts of Alaria?

A

1 is snail
2 is frog or toad
paratenic hosts- frogs, rodents, snakes etc

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40
Q

Where do cycles of Alaria primarily occur?

A

primarily in northern half of US

can occur in dogs/cats allowed to roam

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41
Q

Describe the adult Alaria

A

small flukes ~2-6mm long

anterior portion of body expanded and flattened

posterior body is rounded

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42
Q

Is there anything special about Alaria eggs?

A

meh i guess the very faint suture line for the operculum?

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43
Q

Alarie life cycle… GO!

A

DH ingests paratenic or IH2

mesocercaria released from muscles, migrate to lungs become metacercaria

migrates via blodd, or body cavities to lungs

coughed up/swallowed

develop to adults in SI

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44
Q

Clinical signs associated w/ Alaria

A

usually asymptomatic

heavy infection- duodentitis

wandering worms- associated pathology

adults are short lived

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45
Q

What happens if a human is an accidental host how deos it happen?

A

Fatalities associated w/ eating frog legs

ingest mesocercaria in PH of 2nd IH

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46
Q

___ this fluke is associated w/ crayfish

A

Paragonimus kellicoti

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47
Q

What are the hosts of Paragonimus kellicoti?

A

natural DH: mink, muskrat,
IH1 aquatic or amphibious snails
IH2 fresh water crayfish

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48
Q

How is DH infected with Paragonimus kellicoti?

A

Eats crayfish containing metacercaria

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49
Q

What do teh adult Paragonimus look like?

A

kinda like Mr potatoehead…
1.2 to 3/4 inch ling, ovoid, fleshy
reddish grey to mottled when fresh
SPINES ON THE TEGUMENT

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50
Q

What is teh key characterisitc of P.. kellicoti eggs?

A

distinctive operculum with thickened collar at suture line

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51
Q

What is Paragonimus life cycel in the DH?

A

Metacercariae excyst in gut

enter peritoneal cavity

migrate through diaphragm to lungs

penetreate lungs

mature to adults in cycsts (2 flukes/cyst

cyst comm w/ bronchioles

eggs coughed up, swallowed passed in feces

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52
Q

What are the clinical signs of P. kellicoti?

A
respiratory signs
lethargy
intermittent cough
rusty colored sputum
death if infection severe
cysts develop in other organs
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53
Q

What is the pathology associated w/ larval migration of P. kellicoti?

A

eosinophilic peritonities, pleuritis, myositis

multifocal pleural hemorrhages

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54
Q

What do the cysts associated with adult P. kellitcoti look like?

A

reddish purple cysts 2-3cm in lung paranchyma, contain brownish fluid

thick wall

often near lung surface

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55
Q

what is the pathology of adult P. kellicoti flukes?

A

In the lungs so…
chronic bronchitis- hyperplasia of epithelium

chronic eosinophilic granulomatous pneumonia associated w. degenerating eggs in alveoli

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56
Q

How is Paragonimus kellicoti diagnosed?

A

detect eggs in feces, sputum, or tracheal wash by flotation or sedimentation

detect cysts in the lungs w/ radiographs

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57
Q

T/F Paragonimus kellicoti has a thing for the left cranial lung libe

A

FALSE it is the right caudal lung lobe

58
Q

T/F the detection of cysts on a radiograph is definitive for diagnosing Paragonimus kellicoti

A

False, it is only suggestive

59
Q

What is used to treat P/ kellicoti infections?

A

All extra label drugs,
Praziquantel
Clinics at ISU use Fenbendazole
Albendazole

60
Q

Infections with ____ is referred to as lizard poisoning

A

PLatynosomum fastosum

61
Q

What species is known for Platynsomomum fastosum infections?

A

Occurs in cats in the tropics, souther USA, Hawaii

62
Q

What are the hosts of P. fastosum?

A

DH cats

IH snails, reptiles/amphibians

63
Q

Describe the adults of P. fastosum:

A

tiny flukes, mainly in liver and bile ducts

cause hepatic dysfunction

64
Q

CLin signs assocaited w/ Patynosomum fastosum:

A

anorexia, diarrhea, vomiting, ICTERUS

has been associaed w/ hepatic neoplasia

65
Q

____ is used to treat the liver fluke P. fastosum

A

Praziquantel

66
Q

What are the 3 important liver flukes?

A

Fasciola hepatica- common liver fluke

Fascioloides magna- large american liver fluke

Dicrocoelium dendriticum- lancet fluke

67
Q

____ most economically impotant and common fluke of RMTs worldwide wide wide

A

Fasciola hepatica

68
Q

F. hepatica casues:

A

fascioliasis “liver rot”

69
Q

Where is F. hepatica edemic? do we see it in MW?

A

Edemic to Gulf coast/Pacific NW, but cattle are shipped errywhere

70
Q

Whats host situation for Fasciola hepatica?

A

DH: numerous species including man, just about all RMTs CATTLE ARE THE IMPORTANT ONE

IH lymneid snails, right handed shell? amphibious

71
Q

Where do you finf F. hepatica adults?

A

bile ducts, pass eggs via bile to GI tract and out feces

72
Q

How long does miracidium live in water berfore it dies?

A

Develops in the egg in water,

ciliated, swims inseach of smail, can survive 12 hours

undergoes asexual reproduction in snail

73
Q

What stage of F. hepatica emerges from the snail and how many of them are there?

A

Cercaria emerge from snail… kinda look like a tad pole…

one little fucker miracidium produces 500 of those little bastards

74
Q

What happens to the F. hepatica cercaria once they leave the snail?

A

encyst on vergetation as metacercaria

plants on edge of strea,/pond
await ingestion by DH
can survive about a year under ideal conditions, 1-2 months on silage

killed by heat dessication-

75
Q

What is dessiccation?

A

Brewer must have been on cross word kick because it make more sense to just say drying out

76
Q

What path do metacercariae take once eaten?

A

excyst in intestinf, pentrate gut wall, migrate in peritoneal cavity for several days

penetrate liver capsule
wander around for 7 days
enter bile duct and mature to adults

77
Q

THE SECOND LECTURE OF TREMATODES…. BREWER GAVE US A LIST OF WORMS/HOST/ADUTLS/FUNCFACTS… BE ABLE TO LIST IT OUT

A

WE WILL DO THIS ONCE WE REVIEW… JUST PUT THIS IN HERE FOR A GOOD REVIEW

78
Q

What are the 3 parts of a miracidium?

A

apical papilla
Eye spots
germ cells

79
Q

What are apical papilla?

A

Miracidum structure contian glands that produce enzymes to facilitate entry into snail tissue

80
Q

What are eye spots?

A

Miracidum structure for seeing!

81
Q

What are germ cells?

A

Miracidum structure cells divide asexually to from the next larval generation

82
Q

What structures do sporocytes lack ?

A

HAVE a tegument and germ cells

NO GI TRACT

83
Q

What are redia?

A

Pharynx/intestine, feeds on snail tissue

84
Q

What are the three ways sporocysts develops into carcaria?

A

Mother sporocyst-> daughter sporocyst-> Cercaria

Mother sporocyst-> mother redia-> daughter redia-> Cercaria

Mother sporocyst-> mother redia->cercaria

85
Q

What is a cercariae?

A

immature adult with a GI tract excretory system but no gonads

free swimming

86
Q

When is metacercaria formed?

A

when cercaria lose their tail and become enclsoed in a cyst

secretions from the aprasite and sometimes the 2 IH contribute to the cyst

contains most structures of adults but no egg pdx

87
Q

What do F. hepatica adutls look like?

A
1/2 to 1 in
flat
leaf shaped
anterior comes to shoulders
reddish-grey brown
88
Q

anything characteristic about eggs?

A

look strongyle type ish but much bigger

89
Q

T/F best method for detection of F. hepatica eggs is a liver tissue smear

A

NO.. that doesnt evn make sense… it is sedimentation

90
Q

What is the ideal sanil habitiat?

A

slightly acidic soil plus slow moving water

91
Q

What do snails do in dry/freezing conditions?

A

estivate

parasites survive in estivating snails

92
Q

What effects F. hepatica transmission in regards to snails?

A

Transmission highly dependent on weather

influences numbers and survival of snails

large pop can build quickly

wet conditions can support snails

BUT dry conditions push cattle to wet areas.. so incidence increases

93
Q

What are the signs of acute fascioliasis

A

Due to larval migrations in the liver

anorexia, depression, weakness

possible sudden death

94
Q

T/F Fasciolasis is more of a chronic issue in cattle

A

True

95
Q

What determines the pathogenesis of larval migration of F. hepatica?

A

determined by numbers

hemorrhage +/- death if high number of larvae penetrate liver capsule

migration in liver destroys parenchyma and pdx hemorrhagic tracts “liver rot” that becomes fibrotic

reduced capacity to pdx edema

96
Q

What does the impeded liver fx w/ F. hepatica lead to grossly?

A

Decreased pdx of albumin decreases oncotic pressure resulting in edema

BOTTLE JAW

97
Q

If you see a RMT with bottle jaw what are your top three differentials

A

haemonchus
bunostomum
F. hepaticas

98
Q

What clinical signs are associated w/ chronic fascioliasis?

A
adults in bile ducts
anemia, pale mucous membranes +/- icterus
bottle jaw
disrupted digestion
loss of condition, decreased pdx
death, more likely in sheep
NON seasonal, liver damage is cumulative
99
Q

Adult Fasciola hepatica pdx____ that inhibits erythropoiesis

A

proline

100
Q

What causes the physical damge to liver assocaited w/ F hepatica?

A

SPINES

101
Q

What gross lesion of the liver is associated with Fascioliasis?

A

pipe stem liver

adults in bile ducts cause bile duct hyperplasia, fibrosis and calcification

102
Q

What is blacks disease?

A

Compication of Fasciolasis
Clostridium novyi
larval fluke migration creates ideal conditions for it to proliferate- anearobic necrotic areas
acutely fatal in sheep

103
Q

T/F acute fascioliasis is undetectable

A

TRUE

104
Q

How do we diagnose fasciolaiss?

A

exposure to edemic areas
detect eggs by fecal sedimentation
fluke finder
find them at necropsy/slaughter

105
Q

What is used to treat fascioliasis

A

Clorsulon
albendazole

both labeled for cattle only

106
Q

What is clorsulon?

A

inhibits metabolic enzymes of wrom (3 phophoglycerate kinase and phosphoglyceromutase

107
Q

What is albendazole?

A

kills adults only

terratogen- not for use in oprego animals

108
Q

How do you prevent/control F. hepatica?

A

manage snail habitat… fence off wet areas, drain them

Prophylatic use of clorsulon

109
Q

____ known as the large North American Lever fluke

A

Fascioloides magna

110
Q

Where is Fascioloides magna edemic?

A

morthern MN, WI, MI

areas of NW and SW US

111
Q

Whats the sit rep on hosts for Fascioloides magna?

A

Natural DH- white tailed deer

accidental host- domestic RMT, other cervids, camelids

IH- aquatic right handed lymneid snails

112
Q

T?F fasciloides magna adults are 3-4 inches with broad god like shoulders

A

FALSE are you effing kidding me? they dont have shoulders

113
Q

Outline the life cycle of F. magna real quick

A

Miracidium develops in egg

hatches and infects snail-> cercariae

cercaria encysts as metacercariae on aquatic vegetation

DH ingests vegetation

114
Q

Fascioloides life cycle in white tailed deer

A

adults in thin-walled in liver parenchyma

cysts

115
Q

Clinical signs accidental hosts infected with Fascioloides magna:

A

Moose, cattle, pigs, camelids

flukes walled off in liver parenchyma in fibrous capsules

eggs cant exit, so infection not patent

asymptomatic, but can occur w/ heavy infections

livers condemned

116
Q

What are clinical signs of accidental hosts in Sheep goats

A

sheep/gpats highly susceptible i worm can be lethal

extensive liver necrosis, hemorrhage occurs

unable to stop migration
larvae often wander into other organs

seasonal in MW dec-feb

117
Q

You cut into a liver and see cysts contains some black shit… also notice the black stuff in tracts and draining lymph nodes… the black stuff is actually ____ and is associated with ______ infection

A

“Fluke puke”

Fascioloides magna

118
Q

T/F best way to diagnose F. magna is to performa fecal flaot

A

FALSE they are useless;

best way is history- grazing in edemic area

necropsy or slaughter, detect flukes/vomit

119
Q

T/F Albendazole is the best drug to tx F. magna

A

True; however both albendazole and clorsulon are less effective, recommend a double dose

albendandazole is best choice

prevent by keeping WTD out of pastures draining/fence off water

120
Q

____ distribution is limited to NY, PA and adjacent states

A

Dicrocoelium dendriticum

121
Q

Host populations for Dicrocoelium dendriticum

A

DH domestic/wild RMT, uncommon in cattle

IH1 terrestrial snail
IH2 ants

122
Q

Important D. dendriticum egg facts

A

nothing special, really small 2/3 the size of hook worm look like fungal spores, have to use sedimentation

123
Q

Where are the adult D. dendriticum loacted?

A

in bile ducts, pass eggs in feces

124
Q

LC Dicrocoelium dendriticum?

A

eggs ingested by land snail

asexual generations -> cercaria

cercaria leave snail in slime balls 200-400 cercariae

Ants eat slime ball

affect ant behavior, ants attach to herbage to be eaten

excyst in GI tract

infect liver/bile ducts

125
Q

T/F Dicrocoelium dendritica larva excyst and travel through the peritoneal cavity to liver

A

FALSE migrate up intestine to liver and bile ducts, NO MIGRATION IN PERITONEAL CAVITY

126
Q

What are the gross lesions assocaited with dicrocoelium dendriticum?

A

Bile ducts thickened/distened

liver cirrhoisis

127
Q

Diagnosis/Tx

A

diagnosed at necropsy or slaughter

Tx? nothing

albendazole/clorsulon onlything

128
Q

___ these RMT flukes look like large rice crispies

A

Paramphistomum spp

129
Q

Anything special about LC of Paramphistomum

A

Same shit except metececaria excyst from vegetation and migrate cranieally to duodenmum

130
Q

Anyhting special about Paramphistomum eggs?

A

very similar to Fasciola hepatica eggs

larger than liver fluke eggs

pale grey-green vs yellow/gold of liver flukes

131
Q

What are the 2 rumen flukes and what species do tehy infect?

A

Paramphistomum spp cattle wild deer; more common in moose/deer

Cotylophoron spp
sheep goats

132
Q

____ causes one of the most importatn helminth infections in humans

A

Schistosoma

133
Q

___ is the disease casued by Schistosoma

A

“Schistosomiasis” or “bilharzia”

134
Q

Important things about the LC of Schistosoma

A

adults in MESENTERIC VEINS of SI/LI?venous plexus of bladder

Sheds eggs in feces

Miracidium hatch and BURROW INTO SNAIL

NO REDIA stage goes directly to cerciae

Furocercous leave the snail 200,000/singel miradium

135
Q

What happens when ceracria of Schistosoma find a human?

A

release histolytic enzymes and burrow into skin

loose tails and become schistosomula

enter the blood, reach liver mature to adults and mate

mated adults migrate via hepatic vein to venules pdx eggs

136
Q

T/F schistosoma is dieciuos

A

true

137
Q

WHat is the gynecophoral canal?

A

ventral longitudinal groove in which the females resides

138
Q

What causes the pathology associated w/ schitosoma?

A

THE EGGS, incite a granulomatous inflammation

139
Q

Prevention/Control of schistosomes

A

education- dont shit in the water then get in it

treat- as many people as possible

Snail control- molluscides

Ceracarial barriers- investigating skin drugs that prevent penetration

140
Q

What are the schistosomes in MW where are they found

A

Gigantobilharzia
adultslive in mesenteric vessels of grackles/redwinged balck birds

Trichobilharzia
mesenteric vessels of ducks/geese

Schistosomatium
mesenteric veins of muskrats/meadow voles

141
Q

disease commonly know as swimmers itch.. what is it caused by

A

Cercarial dermatitis

caused by trematodes of birds

cercaria from snails penetrate skin, cause damge/inflammation die there

drying off stimulates penetration- rinse off?

142
Q

The whole even numbers thing again

A

fuck off dude