Enoplids Flashcards
Genral features of Enoplids
Adults have no tail, body ends at anus
L1 infective ecept for D. Renale
L1 has styled (onchiostyle)
What is an onchiostyle
tooth like spear in buccal cavity
What is the one key feature of the super family Trichinelloidea
Stichosome, narrow tube surrounded by large grand cells- stichocytes
Common name for Trichuris spp
whip worms
Where are adult Trichuris found?
lower GI tract
T/F the posterior end of the Trichuris worm is attached to the gut mucosa
FALSE; anterior end is loosely stitched to into the gut epithelium, posterior end is free in the lumen
T/F Trichuri eggs cannot be distinguished from similar looking eggs
FALSE; trichuris is the inly ine that is symmetrical when you draw a line through the opercula
What are opercula?
they are the plugs present on eggs
T/F trichuris lay non embryonated eggs
True
Where does trichuris L1 larvae develop?
in the environment
What is the intermediate host of Trichuris spp
there isnt one, direct life cycle
What is larval migration patter of Trichuris
undergo mucosal migration in the Large intestinal epithelium
What animals are most affected by trichuris?
most severe in young animals
What will you see in infections with a heavy Trichuris adult population
Inflammation associated w/ attachment to the mucosal epithelium
Pigs most common species
Fresh (FRANK) blood vs melena (Hookworms)
bouts of diarrhea
How is Trichuris diagnosed?
Centrifugal flotation in sugar, must differentiate from cappilarid eggs (asymmetrical/banana shaped
Diagnosed at necropsy
T/F Pyrantel is the drug of choice for Trichuris infection
FALSE- nicotinic antimicrobials do not work
NO
Levamisole, Pyrantel, Morantel
_____ is used to treat Trichuris while ____ and ____ are the best ways to control it.
Macrocyclic lactones- benzimidazoles (some HW preventatives milbemycin oxime and moxidectin also work)
Sanitation- remove feces before L1 develops
Avoiding housing on soil
What species is known for recurrent Trichuris infections? Why?
Dogs- reinfection by infective eggs in the environmet
continued post tx of larval stages- larvae are less susceptible to anthelmintics
How do you prevent recurrence of trichuris infections?
prevent re-exposure to eggs in environment
retreat monthly 3x to kill maturing larvae
monthly heartworm preventative w/ activity against whipworms
What are the general characteristic of trichenella adults
very small, hair like 1.5 to 3 mm
females are larger, viviparous
What is special about the transmission of trichinella spp?
2 intermediate hosts
A single host has both infective L1 and adult stages of Trichinella
simultaneously serves as both Definitive and intermediate host
Transmission of Trichinella requires_____
ingestion of under cooked meat (Host 1)
Outline the life cycle of Trichinella in host #1
adults embedded in SI epithelium
Females produce pre-larvae that invade blood/lymph
invade striated muscle cell and mature to L1
develop gonadal primordia
What is a “nurse cell”
striated muscle cell that nourishes and protects infective L1 Trichinella spp.
What are the preferred sites pre-larvae Trichinella invade?
diaphragm, tongue, intercostals, biceps, deltoids, gastrocnemius
What happens to L1 in muscle cells after 1 year?
they will calcify
Outline the life cycle of Trichinella in host #2
Host 2 ingests muslce of Host 1
L1 released in small intestine, invade epithelium, mature to adults
Adults mate, male dies
Female pdx prelarvae ~2 days, repeat Host1 cycle
What are teh 2 cycles of Trichinella spiralis?
Urban Cycle
Sylvatic Cycle
What is the Urban cycle of T. spiralis?
Involves swine, rates, humans
Muscle w/ L1 ingested
undercooked meat
What is the sylvatic cycle of T. spiralis?
maintenance of infection in wild animal populations
What are the common ways humans are infected w/ T. spiralis?
usually undercooked meat- pork/bear
horse meat in Europe, other herbivores and dogs are associated with infection (fed table scraps/feeds w/ animal protein
What are the human clinical signs 1-2 weeks PI with T. spiralis?
nausea, vomiting, diarrhea, abdominal pain- super vague