Treatment of hypertension Flashcards

1
Q

How do you assess the risk of hypertension

A
Previous MI, stroke, IHD
Smoking
Diabetes mellitus
Hypercholesterolaemia
Family history ( heart disease) 
Physical Examination
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2
Q

What must you asses on clinical finding of hypertension

A

Assses for end organ damage,

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3
Q

What are the different techniques used to assess for end organ damage in hypertension

A

Heart -
ECG + Echocardiogram

Renal -
Renal ultrasound
Assses renal function - GFR

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4
Q

On the assessment of hypertension, what types of treatable cases do you screen for

A

Renal artery stenosis/FMD
Cushings disease
Conn’s Syndrome
Sleep apnoea

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5
Q

At what percentage risk factor for CVD should treatment be started

A

20% risk

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6
Q

why should people with low risk at a young age but high BP be treated

A

As damage will increase with time, as the overall risk is only low now due to your age

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7
Q

Why should women with low risk but high blood pressure be treated

A

As women going on to become pregnant at a much higher risk of pre-eclampia which threatens both mothers and childs life

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8
Q

What method is used in the treatment plan of hypertension

A

A stepped approach using the low does of several drugs

using lowest dose and working way up, try and minimise constant change of drug

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9
Q

When would you offer stage one hypertensive treatment

A

people aged under 80 years with ABPM >140/90
with one or more of the following:

target organ damage

established cardiovascular disease

renal disease

diabetes

a 10-year cardiovascular risk equivalent to 20% or greater.

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10
Q

When would you offer stage 2 treatment of hypertension

A

ABPM> 160/100

risk and age doesn’t matter now

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11
Q

What strength of treatment does those over 80 years receive, and what is take into consideration

A

same antihypertensive drug treatment as people aged 55–80 years

co morbidities

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12
Q

What is the blood pressure target for those over 80 years, and why is it this

A

<140/90
Blood pressure is a higher target, so have a little more risk but therefore have a lower risk of falling over - improve quality of life

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13
Q

In step 1 hypertensive treatment when do you offer a calcium channel blocker

A

to people aged over 55 years and to black people of African or Caribbean family origin of any age

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14
Q

When would a calcium channel blocker be unsuitable in stage 1 hypersensitivity what would be offered an alternative

A

intolerance or if there is evidence of heart failure - oedema
or
high risk of heart failure

thiazide like diuretic

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15
Q

When would you offer ACEI/ARB in step 1 hypertension treatment

A

Patient under 55

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16
Q

Who is not suitable for ACEI/ ARB in step 1 hypertension treatment

A

Afro Caribbean
Women of child bearing
patients over 55

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17
Q

What is step 2 hypertension treatment

A

Add Thiazide-type diuretic such as clortalidone or indapamide to
CCB or ACEI/ARB

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18
Q

What is stage 3 hypertension treatment

A

Add CCB, ACEI, Diuretic together

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19
Q

When would you consider step 4 hypertension treatment and what do you need to take into account

A

For treatment of resistant hypertension

blood potassium level

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20
Q

What is stage 4 treatment if the blood potassium level is 4.5 mmol/l or lower

A

Consider further diuretic therapy with low-dose spironolactone (25 mg once daily)

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21
Q

What is stage 4 treatment if the blood potassium level is higher than 4.5 mmol/l

A

Consider higher-dose thiazide-like diuretic treatment

22
Q

What patients do you have to be cautious of in stage 4 treatment

A

patients with a reduced estimated GFR because they have an increased risk of hyperkalaemia.

23
Q

Examples of Angiotensin Converting Enzyme

Inhibitors

A

Ramipril, Perindopril

24
Q

How does ACEI work

A

Competitively inhibit the actions of angiotensin converting enzyme (ACE) prevents the activation of angiotensin II
preventing vasocontriction and and prevents hypertrophogenic

25
Q

Patients with what conditions should not receive ACEI and why

A

Patients with

Renal artery stenosis / Renal failure
(ACEI reduces rena function further)

Diabetes - underlying renal impairment

Hyperkalaemia
(going to increase potassium levels further)

26
Q

What is the side effect of ACEI

A
cough
first dose hypotension
taste disturbance
renal impairment
angioneurotic oedema
27
Q

What drug interactions with ACEI can cause Hyperkalaemia

A

Potassium supplements

Potassium sparing diuretics

28
Q

What is the result of ACEI and NSAIDS interactions

A

Precipitate acute renal failure

29
Q

What is examples of Angiotensin II Antagonists (ARB)

A

LOSARTAN, VALSARTAN, CANDESARTAN, IRBESARTAN

30
Q

How does Angiotensin II Antagonists (ARB) work

A

angiotensin II antagonists competitively block the actions of angiotensin II at the angiotensin AT1 receptor

31
Q

What is the advantage of ARB over ACEI

A

No cough

32
Q

How does ACEI cause hyperkalemia

A

Because its a Potassium conservation

33
Q

What is examples of calcium channel blockers

A

Vasodilator
Amlodipine/Felodipine

Rate limiting
Verapamil/Diltiazem

34
Q

How does calcium channel blockers work

A

blocking the L type calcium channels
selectivity between vascular and cardiac L type channels
relaxing large and small arteries and reducing peripheral resistance
reducing cardiac output

35
Q

What is the side effects of CBB

A

Flushing
Headache
Ankle oedema (Heart failure/MI)
Indigestion and reflux oesophagitis

Rate limiting agents:
Bradycardia
Constipation

36
Q

What is examples Thiazide Type Diuretics

A

Indapamide, Clortalidone

37
Q

What is the further benefit of Thiazide Type Diuretics

A

Proven benefit in treating stoke and myocardial infarction reduction

38
Q

What is the mechanism of action of the thiazide type diuretics

A

Block reabsorption of sodium,

Increasing urine concentration

therefore reducing blood volume

39
Q

What is examples of less commonly used agents in the treatment of hypertension

A

Alpha-adrenoceptor antagonists -

Centrally acting agents

Vasodilators

Beta blockers

40
Q

What is an examples of a Alpha-adrenoceptor antagonists

A

DOXAZOSIN

41
Q

How does Alpha-adrenoceptor antagonists work

A

Selectively block post synaptic 1-adrenoceptors

Prevent arterial constriction

42
Q

What is the side effects of Alpha-adrenoceptor antagonists

A

First dose hypotension
Dizziness
Dry mouth
Headache

43
Q

What is an example of a Centrally Acting Agents

A

METHYLDOPA

MOXONIDINE -

44
Q

How does central acting agents work

A

lower your heart rate and reduce your blood pressure. They work by preventing your brain from sending signals to your nervous system to speed up your heart rate and narrow your blood vessels

45
Q

When are central acting agents most likely to be used

A

Main use is in the treatment of hypertension of pregnancy

46
Q

What is the side effect of central acting agents

A

Sedation and drowsiness
Dry mouth and nasal congestion
Orthostatic hypotension

47
Q

What is the recommended drugs pre pregnancy and during pregnancy

A
Pre -
CBB(Nifedipine MR)  
Centrally acting agents (Methyl dopa)
Beta Blockers (Atenolol, Labetalol)
Pregnant -  add thiazide diuretic and/or amlodipine
48
Q

How do you treat preeclampsia

A

Usual anithypertensive medication

Plus intravenous
beta blockers - esmolol, labetalol
Vasodilators - hydralazine

49
Q

what is the common risk factor for preeclampsia

A

existing hypertension

50
Q

What are the signs of preeclampsia

A

from about 20 weeks BP>140/90 mmHg