Treatment For Bronchail Asthma Flashcards
Asthma is a condition caused by
Hypersensitivity of the bronchus which leads to inflammation
Methylxanthine drugs for asthma includes
Aminophylline
Theophylline
Classes of drugs used to treat asthma include ( mention 7)
1) Beta Adrenergic agonist drug
2) Muscarinic/anticholinergic antagonist drug
3) mast cell stabilizers
4) Leucotrines receptor inhibitor
5) lipoxygenase inhibitor
6) anti IG E drug
SAMA drugs include ( short acting Muscarinic antagonist drug )
Ipratropium
LAMA drugs include ( long acting Muscarinic antagonist drug )
Titotropium
Zilueton is a drug used for
And it’s mechanism of action
An asthma drug
It does it by inhibiting lipoxygenase enzyme ( in Leucotrines synthesis)
SABA drugs include ( short acting beta 2 Adrenergic agonist drug )
Salbutamol( Albuterol)
Levabuterol
Terbutaline
Metaproterenol
Pirbuterol
LABA drugs include ( long acting beta Adrenergic agonist drug )
Salmeterol
Vilaterol
Formoterol
Mechanism of action of beta Adrenergic drugs in asthma is
Increase CAMP in the cell leading to relaxation of respiratory tract
Methylxanthine mechanism of action is
Inhibiting phosphodiesterase ( an enzyme that cuts CAMP to AMP )
Thereby increasing the half life of Camp
Which of these is not an asthma drug
Aminophylline
Clofazimine
Montelukast
Ipratropium
Clofazimine
Leucotrine receptor inhibitior drug include
Montelukast
Zafirlukast
Mast cell stabilizer drugs include
Nedocromil sodium
Sodium chromoglycate
Anti IGE drugs include
Omelizumab
Omelizumab
Is an asthma drugs that inhibits IGE antibody secretion
Short acting beta 2 agonist drug used to treat asthma is
Albuterol
Levabuterol
Inhaled corticosteroids used to treat asthma is
Beclomethasone
Budesonide
Ciclesonide
Flunisolide
Triamcinalone
Mast cell stabilizers include
Nedocromil
Cromolyn
What reduces FEV1?
Inflammation enzymes
Histamine
Prostaglandin
Trypase
Leucotrine
Platelet activating factor
What is FEV??
This is also called forced expiratory volume
The amount of air one can exhale after a forced inspiration
Non selective adrenoreceptor drugs in asthma treatment is
Epinephrine
Ephedrine
What is the side effect of using epinephrine in treating asthma
Epinephrine binds to both alpha and beta blockers
It can bind to beta 1 and cause tachycardia, arrhythmia, worsen angina pectoris
Non selective beta agonist
Salbutamol
Caffeine
Isoproterenol
Levabuterol
Loperamide
Isoproterenol / isoprenaline
Beta 2 agonist mechanism of action on treating asthma
They activate adenyl cyclase which increases Camp causing bronchodilatoin
Tachyphylaxis is defined as
Sudden increase in tolerance to a drug
Cure it by increasing the dose
Drugs that are Methylxanthine are
Aminophylline (theophylline)
Caffeine
Theobromine
Side effect of Methylxanthine include
Cns- drowsiness tremor insomnia convulsion
Cardiac- hypotension tachycardia arrhythmia palpitation
Kidney- diuresis
Git- vomiting diahreeal aggravates peptic ulcer
Methylxanthine are preferably used to treat
COPD ( chronic obstructive pulmonary disease)
Anticholinergices include
Ipratropium (short acting)
Titotropomium ( long acting)
Zilueton ;
Inhibits 5-lipoxygenase enzyme
Ketotifen;
Mast cell stabilizer that inhibits H1
Histamine receptor blocker
A mast cell stabilizer used a prophylactic drug is ———
Sodium chromoglycate
Sodium chromoglycate is used in the treatment of
Allergic asthma
Allergic conjunctivitis
Allergic rhinitis
Allergic dermatitis
Glucocorticoids MOA in asthma is
They secrete lipocortin which inhibits phospholipase a2
Inhibiting the synthesis of Thromboxane, prostaglandin
Side effects of glucocorticoids
Cause edema ( retains sodium and water )
Osteoporosis
Cause hypertension
Which of these does not have bronchodilation properties
Albuterol
Aminophylline
Sodium chromoglycate
Titotropium
Sodium chromoglycate
Montelukast mechanism of action
They are leucotrine receptor antagonist by competitively blocking cystienyl leucotrines ( LTC4,LTD4,LTE4)
Inhaled glucocorticoids include
Beclamethasone
Fluticasone
Flunisolide
Budesonide
Traimcinalone
Systematic corticosteroids used in asthma is
Prednisone
Predisolone
Hydrocortisone
Drugs used to treat severe acute asthma ( asthamticus) is
Systemic glucocorticoids; hydrocortisone
Nebulized oxygen
Anticholinergice
Selective beta 2 agonist
Iv fluid to cure dehydration
Status asthmaticus also known as ————— is treated with
Severe acute asthma attack
Iv hydrocortisone
Isoprenaline ;
A non selective beta agonist drug
Also called Isoproterenol
