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Pharmacology 2nd Block > Treatment For Bronchail Asthma > Flashcards

Treatment For Bronchail Asthma Flashcards

1
Q

Asthma is a condition caused by

A

Hypersensitivity of the bronchus which leads to inflammation

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2
Q

Methylxanthine drugs for asthma includes

A

Aminophylline
Theophylline

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3
Q

Classes of drugs used to treat asthma include ( mention 7)

A

1) Beta Adrenergic agonist drug
2) Muscarinic/anticholinergic antagonist drug
3) mast cell stabilizers
4) Leucotrines receptor inhibitor
5) lipoxygenase inhibitor
6) anti IG E drug

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4
Q

SAMA drugs include ( short acting Muscarinic antagonist drug )

A

Ipratropium

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5
Q

LAMA drugs include ( long acting Muscarinic antagonist drug )

A

Titotropium

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6
Q

Zilueton is a drug used for
And it’s mechanism of action

A

An asthma drug

It does it by inhibiting lipoxygenase enzyme ( in Leucotrines synthesis)

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7
Q

SABA drugs include ( short acting beta 2 Adrenergic agonist drug )

A

Salbutamol( Albuterol)
Levabuterol
Terbutaline
Metaproterenol
Pirbuterol

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8
Q

LABA drugs include ( long acting beta Adrenergic agonist drug )

A

Salmeterol
Vilaterol
Formoterol

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9
Q

Mechanism of action of beta Adrenergic drugs in asthma is

A

Increase CAMP in the cell leading to relaxation of respiratory tract

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10
Q

Methylxanthine mechanism of action is

A

Inhibiting phosphodiesterase ( an enzyme that cuts CAMP to AMP )

Thereby increasing the half life of Camp

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11
Q

Which of these is not an asthma drug

Aminophylline
Clofazimine
Montelukast
Ipratropium

A

Clofazimine

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12
Q

Leucotrine receptor inhibitior drug include

A

Montelukast
Zafirlukast

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13
Q

Mast cell stabilizer drugs include

A

Nedocromil sodium
Sodium chromoglycate

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14
Q

Anti IGE drugs include

A

Omelizumab

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15
Q

Omelizumab

A

Is an asthma drugs that inhibits IGE antibody secretion

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16
Q

Short acting beta 2 agonist drug used to treat asthma is

A

Albuterol
Levabuterol

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17
Q

Inhaled corticosteroids used to treat asthma is

A

Beclomethasone
Budesonide
Ciclesonide
Flunisolide
Triamcinalone

18
Q

Mast cell stabilizers include

A

Nedocromil
Cromolyn

19
Q

What reduces FEV1?

A

Inflammation enzymes

Histamine
Prostaglandin
Trypase
Leucotrine
Platelet activating factor

20
Q

What is FEV??

A

This is also called forced expiratory volume

The amount of air one can exhale after a forced inspiration

21
Q

Non selective adrenoreceptor drugs in asthma treatment is

A

Epinephrine
Ephedrine

22
Q

What is the side effect of using epinephrine in treating asthma

A

Epinephrine binds to both alpha and beta blockers

It can bind to beta 1 and cause tachycardia, arrhythmia, worsen angina pectoris

23
Q

Non selective beta agonist

Salbutamol
Caffeine
Isoproterenol
Levabuterol
Loperamide

A

Isoproterenol / isoprenaline

24
Q

Beta 2 agonist mechanism of action on treating asthma

A

They activate adenyl cyclase which increases Camp causing bronchodilatoin

25
Q

Tachyphylaxis is defined as

A

Sudden increase in tolerance to a drug

Cure it by increasing the dose

26
Q

Drugs that are Methylxanthine are

A

Aminophylline (theophylline)
Caffeine
Theobromine

27
Q

Side effect of Methylxanthine include

A

Cns- drowsiness tremor insomnia convulsion

Cardiac- hypotension tachycardia arrhythmia palpitation

Kidney- diuresis

Git- vomiting diahreeal aggravates peptic ulcer

28
Q

Methylxanthine are preferably used to treat

A

COPD ( chronic obstructive pulmonary disease)

29
Q

Anticholinergices include

A

Ipratropium (short acting)
Titotropomium ( long acting)

30
Q

Zilueton ;

A

Inhibits 5-lipoxygenase enzyme

31
Q

Ketotifen;

A

Mast cell stabilizer that inhibits H1

Histamine receptor blocker

32
Q

A mast cell stabilizer used a prophylactic drug is ———

A

Sodium chromoglycate

33
Q

Sodium chromoglycate is used in the treatment of

A

Allergic asthma
Allergic conjunctivitis
Allergic rhinitis
Allergic dermatitis

34
Q

Glucocorticoids MOA in asthma is

A

They secrete lipocortin which inhibits phospholipase a2

Inhibiting the synthesis of Thromboxane, prostaglandin

35
Q

Side effects of glucocorticoids

A

Cause edema ( retains sodium and water )

Osteoporosis

Cause hypertension

36
Q

Which of these does not have bronchodilation properties

Albuterol
Aminophylline
Sodium chromoglycate
Titotropium

A

Sodium chromoglycate

37
Q

Montelukast mechanism of action

A

They are leucotrine receptor antagonist by competitively blocking cystienyl leucotrines ( LTC4,LTD4,LTE4)

38
Q

Inhaled glucocorticoids include

A

Beclamethasone
Fluticasone
Flunisolide
Budesonide
Traimcinalone

39
Q

Systematic corticosteroids used in asthma is

A

Prednisone
Predisolone
Hydrocortisone

40
Q

Drugs used to treat severe acute asthma ( asthamticus) is

A

Systemic glucocorticoids; hydrocortisone

Nebulized oxygen
Anticholinergice
Selective beta 2 agonist

Iv fluid to cure dehydration

41
Q

Status asthmaticus also known as ————— is treated with

A

Severe acute asthma attack

Iv hydrocortisone

42
Q

Isoprenaline ;

A

A non selective beta agonist drug

Also called Isoproterenol

Pharmacology 2nd Block (13 decks)

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