Drugs For Peptic Ulcer Flashcards
Acid of the stomach is produced by
Parietal cells
Parietal cells contains what receptor??
Histamine 2
Muscarinic receptor
Gastrin receptor
Antacids;
A peptic ulcer drugs
It is a weak base that reacts with the acid of the stomach to form water and salt
Hcl + NAOH ——-> H20 + NACL
How is acid in the stomach stimulated to form??
When the receptors are stimulated
Adenyl Cyclase is produced
Ca2 ion enters
Protein kinase is activated
Protein kinase causes the release of CAMP
Camp opens the H+\k+ channel
Forming acid
Histamine receptor locations are
H1-
H2-
H3-
H4-
H1- allergic inflammation
H2- gastric secretion
H3- neuro transmission ( cns)
H4- immunomodulation
Histamine 2 antagonist drugs includes
Ranitidine
Cimetidine
Nizatidine
Famotidine
Histamine 2 blockers work well with what type of acid release
Nocturnal and fasting acid
H2 antagonist drugs are used for
Peptic ulcer
Proton pumps MOA
1)They are ingested as prodrugs
2)Then absorbed in the intestine
3)Enter the canaliculus of the parietal cell
4)Then activated in the acidic environment of the canaliculus
5) activated to theophillic sulfinamide cation
6) the sulfanimide cation forms a covalent disulfide bond with H+/k+ atpase inactivating the pump
Proton pump drugs include
Omeprazole
Esomeprazole
Lesoprazole
Rabeprazole
Dexlansoprazole
Proton pump is used as a medication in
GERD and H.pylori ulcer
Mucosal protective agent to peptic ulcers include
Sucralfate- forms a paste in water or acidic solution
Misoprostol- prostaglandin agent that cause mucus & bicarbonate release and reduce acid secretion
Bismuth salicylicate and potassium- they coat ulcer wounds
Carbenoxolone
Anti helicobacter pylori drugs include
Amoxicillin
Clarithromycin
Metronidazole
Tinidazole
Tetracycline
