Laxatives Flashcards
Laxatives are drugs used to treat
Constipation
Bulk forming laxatives include
Psyllium
Methyl cellulose
Bran
Calcium polycarbophil
Bulk forming laxative MOA
They are hydrophilic (water loving) so they increase the feaces and liquefy it …. The distension causes the intestine to be stimulated
Stool softeners MOA
They are emollients that add fat and water to stool making it slippery
Side effect of liquid paraffin use is
Pruritus
Drugs that are stool softeners
Liquid paraffin
Docusate sodium
The first Line drug in constipation is
Bulk forming laxatives
Osmotic laxatives; MOA
Reduce water absorption causing the poo to liquefy
Osmotic laxative drug include
Sorbitol
Magnesium hydroxide( milk of magnesia)
Lactulose
Polyethylene glycol
Git stimulant drugs for constipation is
Secca
Aloe
cascara
Bisacodyl
Bisacodyl should be used cautiously to avoid ———
Intestine obstruction
Lubiprostone;
It is a chloride channel actiavtor used to stimulate GIT motility
A chloride channel activator includes;
Ranitidine
Omeprazole
Loperamide
Lubiprostone
Lubiprostone
Tegaserod;
A serotonin 4 receptor agonist drug used as a laxative
A 5-hydroxytryptamine agonist drug
