Transplant Medicine

Question 0

most important HLAs

Answer 0

HLA1A, HLAIb, HLA2DR

Question 1

3 phases of immune response to transplant

Answer 1

recognition of foreign antigen
activation of antigen specific lymphocytes
effect phase of graft reject

Question 2

important for activation

Answer 2

IL2 R (CD25) CD3 R

Question 3

calcineurin

Answer 3

blocks transformation of t cells, which is the biggest boom step

Question 4

triple therapy

Answer 4

calcineurin inhibitors
corticosteroids
azathiprine

Question 5

calcineuron inhibiots

Answer 5

csa cyclosporine

Question 6

mechanism of calcineurin inhib

Answer 6

decrease t cell proliferationa nd cytokine production by blocking calcineurin–>decativate nucler tf of t cells

Question 7

side effects calcineuron inhibitors

Answer 7

nephrotoxicity

neurotoxicity

Question 8

Mycophenolate motefil

Answer 8

selective antimetabolite for both t cells and b cells that works by reversibly inhibiting ionosine monophosphate–>blocks guanosine synthessis

Question 9

Mycophenolate se

Answer 9

Bone marrow suppression

dramatic diarrhea

Question 10

sirolismus (rapamycin

Answer 10

calcineurin inhibitor-binds to mtor and turns off cell proliferation
se- hyperlipidemia

Question 11

alemtuzumab

Answer 11

anticd52-one dose no b or t cells for 4 hrs but last for 18 months

Question 12

rituximab

Answer 12

anti cd 20 antibody used to decrease b cells

Question 13

recipient age

Answer 13

older is better

Question 14

donor age

Answer 14

older is worse

Question 15

races in order

Answer 15

asians>white<black

Question 16

65 years old

Answer 16

this is the infection point

if they are greater than 65, less rejection meds, dont give anticd25 stuff

Question 17

30% of all post-tx infections

Answer 17

UTIs

Question 18

wost of CSA

Answer 18

more HTN, more hirsutism, gingibal hyperplasia, hyperlipidemia, less diabetogenesis NO marrow suppression

Question 19

worst of FK506

Answer 19

no hyperlipidemia, very diabetogenic, no marrow suppression