chronic kidney disease Flashcards
CKD is defined as
GFR less than 60 for > 3 months
as the number of functioning neprhons decreases
more demand per nephron
CGA staging
cause
gfr
albuminuria
to figure out eGFR you must
use the serum certaine and GFR, NOT creatinine alone
preferred scale for adults
albumn/creatinne
preferred scale for kids
protein/creatinine
low GFR
is more than high albumin
pathological progression CKD
tubular atrophy
interstitial fibrosis
glomerular sclerosis
periglomerual fibroiss
assessing proteinuria
do a spot urine same (in AM for kids) if increased risk for CKD do alumin specific dipstick for ACR for adults or a PCR for kids
interventions for CKD
low protein diet oral alkali hyperuricemia-->allopurinol lipids and treatment vit d analogs
comorbidities of CKD
HTN anemia vit d def po4 retnetion metabolic acidosis
preferred agents for HTN CKD
acei or arb
cautions of HTN in CKD
10-20% CREATININEb increase may happen in first 2 weeks, but than stabilizes unless some other issue
NO K supplements and k sparing diuretics
why do patients get anemia
ckd–>decrease epo production by peritubular cells
vit d def and PO4 retnetion lead to
hypo ca–>hyperpth–>osteodystrophy