KD in children Flashcards
ddx hematuria in children
glomerular- glomerulonephritis
non-glomerular- hypercalciruia, infection, trauma, tumor, stones, sickle cell (HITTSS)
three types of acute kidney disease in children
post infectious GN
hemolytic uremic syndrome
henoch sconlein purpura
non-glomerular clinical presentation
localized symptoms, pink-red urine +/ clots, eumorphic rbs
glomerular presentations
brown tea colored urine w/ rbc casts and dysmorphic rbc
main cause of GN in kids
post strep- low c3, strep titers
main cause of nephrotic syndrome
minimal change disease
how do you make minimal change disease
give prednisone and see if responds
based off of negatives for GN
other pediatric nephrotic syndromes
primary- MCD, FGHN, membranous (teens)
Secondary-lupus
fanconi syndrome
decrease reabs in PT of water Na, bicarb, Ca, Po4, uric acid, glucose, amino acid
CP in fanconis
decrease gtrowth
metabolic acidosis
rickets
causes of fanconi
confenital- cystolosis, lowe’s, wilson’s, heritary fructose intolerance
acquired/iatrogenic- aminoglycosides
Gordon’s syndrome
rare mirror image of gitelmans
gain of function upstream activators of NaCl cotransport, so hypercalc, metabolic alkalosis, decreased renin
treatment of gordons
thiazide
Liddle’s treatment
amiloride (no response to spirnolactone)
causes of nephro DI
x linked LOF in V2 R
AR LOF of aquaporin 2
acquired-lithium, tetra
