transplant immunology Flashcards
Graft transplanted from one individual to the same individual
autologous graft
Graft transplanted between two genetically identical (or very similar) individuals
syngenetic graft
Graft between two genetically different individuals
allogenetic graft
transplanting a cell or tissue to the same anatomical site
orthotopic
transplanting a cell or tissue to a different anatomical site
heterotopic
transfer of circulating cells from one individual to another
transfusion
____ immune cells react to allogeneic grafts
alloreactive
rejection of a graft is due to mismatch in ____ molecule; if it does not match, T cells will recognize graft as foreign
MHC
CD4+ T cells require ____ to become activated
antigen + MHC II
CD8+ T cells require _____ to become activated
antigen + MHC I
T cell binds to self MHC and foreign peptide with ____ affinity
high
MHC II + peptide activates CD4+ T cells and T cells produce ____ to help propagate the immune response
cytokines
self MHC molecule presents foreign peptide to T cell selected to recognize ____ weakly, but may recognize ____ complexes well
self MHC; self-MHC/ foreign peptide complexes
two examples of direct alloantigen recognition
- T cell recognizes allogeneic MHC molecule whose structure resembles self MHC+foreign peptide complex
- T cell recognizes structure formed by both allogeneic MHC molecule and bound peptide (self peptide)
If the allogeneic MHC+self peptide
is structurally similar to self MHC and foreign peptide, it will result in _____
T cell activation
When T cells recognize allogeneic MHC (or allogeneic MHC+self peptide) directly it is called ______
direct alloantigen recognition
presentation of processed peptide of allogeneic MHC molecule bound to self MHC molecule
indirect alloantigen recognition