transplant immunology Flashcards

1
Q

Graft transplanted from one individual to the same individual

A

autologous graft

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2
Q

Graft transplanted between two genetically identical (or very similar) individuals

A

syngenetic graft

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3
Q

Graft between two genetically different individuals

A

allogenetic graft

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4
Q

transplanting a cell or tissue to the same anatomical site

A

orthotopic

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5
Q

transplanting a cell or tissue to a different anatomical site

A

heterotopic

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6
Q

transfer of circulating cells from one individual to another

A

transfusion

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7
Q

____ immune cells react to allogeneic grafts

A

alloreactive

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8
Q

rejection of a graft is due to mismatch in ____ molecule; if it does not match, T cells will recognize graft as foreign

A

MHC

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9
Q

CD4+ T cells require ____ to become activated

A

antigen + MHC II

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10
Q

CD8+ T cells require _____ to become activated

A

antigen + MHC I

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11
Q

T cell binds to self MHC and foreign peptide with ____ affinity

A

high

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12
Q

MHC II + peptide activates CD4+ T cells and T cells produce ____ to help propagate the immune response

A

cytokines

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13
Q

self MHC molecule presents foreign peptide to T cell selected to recognize ____ weakly, but may recognize ____ complexes well

A

self MHC; self-MHC/ foreign peptide complexes

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14
Q

two examples of direct alloantigen recognition

A
  1. T cell recognizes allogeneic MHC molecule whose structure resembles self MHC+foreign peptide complex
  2. T cell recognizes structure formed by both allogeneic MHC molecule and bound peptide (self peptide)
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15
Q

If the allogeneic MHC+self peptide

is structurally similar to self MHC and foreign peptide, it will result in _____

A

T cell activation

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16
Q

When T cells recognize allogeneic MHC (or allogeneic MHC+self peptide) directly it is called ______

A

direct alloantigen recognition

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17
Q

presentation of processed peptide of allogeneic MHC molecule bound to self MHC molecule

A

indirect alloantigen recognition

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18
Q

indirect alloantigen recognition is an example of ____ or ____

A

cross presentation; cross priming

19
Q

how do allogeneic T cells lead to graft rejection?

A
  1. hyperacute rejection
  2. acute rejection
  3. chronic rejection
20
Q

hyperacute rejection is characterized by ____ and eventual ____of the graft blood vessel that begins within ____ of the transplant

A

thrombosis formation; occlusion; minutes to hours

21
Q

results of hyperacute rejection

A

complement activation, endothelial damage, inflammation and thrombosis

22
Q

in acute rejection, ____ become activated after about a week and produce cytokines

A

alloreactive T cells

23
Q

results of acute rejection

A

parenchymal cell damage
interstitial inflammation
endothelialitis

24
Q

grafts that survive for 6 months or more can eventually develop ____ due to _____

A

blood vessel thickening; intimal smooth muscle formation

25
Q

results of chronic graft rejection

A

chronic DTH reaction in vessel wall
intimal smooth muscle cell proliferation
vessel occlusion

26
Q

cells from the common myeloid progenitor

A

erythrocytes (RBCs), platelets, basophils, eosinophils, neutrophils, monocytes/macrophages

27
Q

cells from common lymphoid progenitor

A

B lymphocytes, T lymphocytes, NK cells

28
Q

While same immune reactions/rejection can occur with bone marrow transplant, there is also the risk of the graft attacking the host, which is called:

A

graft vs host disease

29
Q

tumor antigens are recognized by _____

A

tumor-specific CD8+ T cells

30
Q

types of tumor antigens recognized by T cells

A
  1. mutated forms of normal self proteins
  2. product of oncogene or mutated tumor suppressor gene
  3. overexpressed or aberrantly expressed self protein
  4. products of oncogenic virus
31
Q

Some cancers can down-regulate the expression of MHCI. Why is this important to the immune system?

A

NK cell becomes activated and can kill infected cell

32
Q

activated NK cells cal produce ____

A

IFN-gamma

33
Q

the production of IFN-gamma is important because?

A

IFN-gamma activates macrophages and allows them to kill phagocytosed tumor cells

34
Q

function of tumor macrophages depends upon the ____

A

cytokine microenvironment

35
Q

____ leads to M1 (or classical) macrophage activation

A

IFN-gamma

36
Q

_____ leads to M2 (or alternative) macrophage activation

A

IL-4, IL-13, IL-10

37
Q

M1 macrophages can suppress tumors/kill tumor cells through _____

A

bactericidal activity
immunostimulation
inflammatory cytokines

38
Q

M2 macrophages can enhance tumors through _____

A

scavenging
tissue repair
matrix remodeling
angiogenesis

39
Q

The principal mechanism of tumor immunity is killing of tumor cells by ____

A

CD8+ cytotoxic T lymphocytes

40
Q

experimental evidence suggests that the CD8+ CTL’s are most effective against _____

A

DNA virus-induced tumors

41
Q

____ may be necessary for CTL activation

A

cross-priming

42
Q

role of CD4+ T cells in CTL differentiation

A
  1. help to activate CD8+ T cells- produce cytokines that stimulate CTL differentiation
  2. produce Th1 cytokines that lead to classical (M1) macrophage activation
43
Q

People with _____ are at an increased risk of developing cancer

A

chronic inflammatory diseases