Antigen Processing/Presentation Flashcards
pattern recognition receptors
mannose receptors
scavenger receptors
toll-like receptors
the process of taking up a microbe, processing the antigens and presenting it to a naive T cell
antigen processing and presentation
primary antigen-presenting cells (professional APC)
dendritic cells
dendritic cells are ____ cells and are the link between ___ and ____ immunity
phagocytic; innate; adaptive
dendritic cells typically express ____ molecules and present antigen peptides within ____ on surface
MHC II; MHC II
monocytes in blood become ____ in tissue; they are ____ cells extremely important for the clearance of _____
macrophages; phagocytic; dead cells and debris
moncytes/macrophages are extremely important for ____
antigen presentation
B cells are ___, part of ____ immunity; they can activate ____(more common in secondary or memory immune responses)
lymphocytes; adaptive
T cells
antigen presentation is a way to concentrate the antigen in areas most likely to come into contact with ____ and ____
T cells; B cells
steps to antigen presentation
- microbe infects host
- microbe is taken up by APC at site of infection
- APC enters lymph circulation and into LN
- Naive T and B cells enter LN from circulation
antigen presenting cells are not limited to ____, ____, and ____; all nucleated cells can present endogenous antigens in association with ____ molecules
dendritic cells; macrophages; B cells
MHC I
the original function of the MHC (major histocompatibility complex) was linked only to ____
graft rejection
MHC was later found to be of critical importance to all ____ involving _____
immune responses; protein antigens
MHCI is found on all ____ cells; ____ protein can bind to MHCI ; MHCI is recognized by ____
found on all nucleated cells
cytoplasmic (intracellular)
CD8+ T cells (cytotoxic T cells)
MHC II is found on ____; ____ proteins bind to MHC II; MHC II is recognized by ____
antigen presenting cells
extracellular
CD4+ T cells (helper T cells)
the process by which antigens are digested and placed on the cell surface with the correct MHC molecule
antigen processing
2 pathways of antigen processing
- extracellular proteins that are internalized by professional APCs into vesicles are processed and displayed by class II MHC molecules
- proteins in the cytosol of nucleated cells are processed and displayed by class I MHC molecules