Transplant

Question 1

Transplant defination

Answer 1

Transplant refers to the transfer of graft or a cell ,tissues organs from one site to another, or one person to another

The individual who donates is called Donar

The individual who receive is called recipients

Question 2

Transplantation classification based on the anatomical site

Answer 2

Orthothotopic
Where tissue is transplanted to anatomical normal site

Heterotropic
Where tissue is transplanted to another site
Thyroid tissue to sub cutaneous site

Question 3

What are vital and static transplant

Answer 3

Vital transplant are the organs which are thought to functioning in the receptor tract body
Eg heart kidney

Static transplant examples are arteri, bone
These are non living sturucture

Question 4

Based on the genetic relationship how the transplant is classified

Answer 4

Allograft
Xenografts
Isograft
Autograft

Question 5

What is histocompatibility

Answer 5

Histocompatibility between graft and recipient
Prevents the rejection

It is nothing but antigenetically similar

Usually autograft and isografts are histocompatible

Also and Zeno are usually incompatible

Question 6

What are transplantation antigens

Answer 6

Transplantation antigens are the antigens of allograft where recipients mount the immune response

Question 7

What are the major and minor transplantation proteins

Answer 7

Major are MHC molecules
And abo and rh blood groups

Minor are
Peptides derived from the normal cellular proteins of donated organs

Question 8

Why the rejection is more when organs are transplant from the male to female than female to male

Answer 8

Graft tissue of male XY
Recipients is XX
So HY antigens are present in the graft
So this does not happen Inthe vice versa

Eichwald slimmer effect

Question 9

What are the types of graft rejection

Answer 9

Hyperacute minutes to hrs
Acute days to weeks
Chronic months to hrs

Question 10

Hyperacute graft rejection

Answer 10

Characterised by the thrombosis of vessels and ischemia necrosis of graft

Mediated by the circulating antibodies specific for antigens on graft endothelial cells

Performed antibodies may be consequences of blood transfusion, transpl,pregnancy

These anti abo anti Hla

Question 11

Acute graft rejection

Answer 11

Occurs in days to weeks after transplantation

Mediated by the T cells mainly cytotoxic occasionally helper T cell and antibodies