Transplant Flashcards
Transplant defination
Transplant refers to the transfer of graft or a cell ,tissues organs from one site to another, or one person to another
The individual who donates is called Donar
The individual who receive is called recipients
Transplantation classification based on the anatomical site
Orthothotopic
Where tissue is transplanted to anatomical normal site
Heterotropic
Where tissue is transplanted to another site
Thyroid tissue to sub cutaneous site
What are vital and static transplant
Vital transplant are the organs which are thought to functioning in the receptor tract body
Eg heart kidney
Static transplant examples are arteri, bone
These are non living sturucture
Based on the genetic relationship how the transplant is classified
Allograft
Xenografts
Isograft
Autograft
What is histocompatibility
Histocompatibility between graft and recipient
Prevents the rejection
It is nothing but antigenetically similar
Usually autograft and isografts are histocompatible
Also and Zeno are usually incompatible
What are transplantation antigens
Transplantation antigens are the antigens of allograft where recipients mount the immune response
What are the major and minor transplantation proteins
Major are MHC molecules
And abo and rh blood groups
Minor are
Peptides derived from the normal cellular proteins of donated organs
Why the rejection is more when organs are transplant from the male to female than female to male
Graft tissue of male XY
Recipients is XX
So HY antigens are present in the graft
So this does not happen Inthe vice versa
Eichwald slimmer effect
What are the types of graft rejection
Hyperacute minutes to hrs
Acute days to weeks
Chronic months to hrs
Hyperacute graft rejection
Characterised by the thrombosis of vessels and ischemia necrosis of graft
Mediated by the circulating antibodies specific for antigens on graft endothelial cells
Performed antibodies may be consequences of blood transfusion, transpl,pregnancy
These anti abo anti Hla
Acute graft rejection
Occurs in days to weeks after transplantation
Mediated by the T cells mainly cytotoxic occasionally helper T cell and antibodies
