Translational Research

Question 1

Name the 5 categories in the spectrum of translational research

Answer 1

T0 - Experimental and applied research

T1 - Translation to humans

T2 - Translation to patients

T3 - Translation to practice

T4 - Translation to communities

Question 2

Describe T0 research

What is it?

What do you do?

What is the goal?

Answer 2

What is it? - Experimental and Applied research

What do you do? - Preclinical and animal studies

Goal? - Defining mechanisms, targets, and lead molecules

Question 3

Describe T1 research

What is it?

What do you do?

What is the goal?

Answer 3

What is it? - Translation to humans

What do you do? - Proof of Concept Phase I Clinical Trials

Goal? - New methods of diagnosis, treatment, and prevention

Question 4

Describe T2 research

What is it?

What do you do?

What is the goal?

Answer 4

What is it? - Translation to Patients

What do you do? - Phase II and Phase III Clinical Trials

Goal? - Controlled studies leading to effective care

Question 5

Describe T4 research

What is it?

What do you do?

What is the goal?

Answer 5

What is it? - Tranlsation to Communities

What do you do? - Population level and outcomes research

Goal? - Population health and how society benefits

Question 6

Describe T3 research

What is it?

What do you do?

What is the goal?

Answer 6

What is it? - Tranlsation to Practice

What do you do? - Phase IV Clinical Trials and Clinical Outcomes

Goal? - Delivery of recommended care to the right patient

Question 7

“Elucidating disease mechanisms and pathophysiology”

This is an example of what kind of translational research?

Answer 7

T0 - Experimental and applied research

Question 8

“Developing novel therapeutic strategies by identifying molecular pathways to target”

This is an example of what kind of translational research?

Answer 8

T0 - Experimental and applied research

Question 9

“Identifying disease biomarkers to monitor disease progression or therapeutic response”

This is an example of what kind of translational research?

Answer 9

T0 - Experimental and applied research

Question 10

“Identifying disease modifiers for feedback for risk stratification”

This is an example of what kind of translational research?

Answer 10

T0 - Experimental and applied research

Question 11

“Is Molecule A safe for treating patients? What are the side effects?”

This is an example of what kind of translational research?

Answer 11

T1 - Translation to humans

Question 12

“Determining how Drug A is metabolized and excreted”

This is an example of what kind of translational research?

Answer 12

T1 - Translation to humans

Question 13

“What is the appropriate dosing of Drug A?”

This is an example of what kind of translational research?

Answer 13

T1 - Translation to Humans

Question 14

“Does Drug A work to prevent Disease X?”

This is an example of what kind of translational research?

Answer 14

T2 - Translation to Patients

Question 15

“Is Drug A better than or non-inferior to current standard of care for Disease X?

This is an example of what kind of translational research?

Answer 15

T2 - Translation to patients

Question 16

“Drug A is superior to current standard of care, but we need to know more about long-term side effects and disease progresion”

This is an example of what kind of translational research?

Answer 16

T3 - Translation to Practice

Question 17

“Leveraging big population data for risk stratification and effectiveness of Drug A”

This is an example of what kind of translational research?

Answer 17

T4 - Translation to communities

Question 18

What is the criteria for a good research question?

Answer 18

It needs to be FINER

F - Feasable

I - Interesting

N - Novel

E - Ethical

R - Relevant

Question 19

What is the difference between an “interesting” question and a “relevant” question?

Answer 19

Interesting = do you, your mentor, the broader community care?

Relevant - Does it contribute important knowledge to the T0-T4 pipeline of your area of study?