Transfusion Medicine

Question 1

What are the contents of cryoprecipitate?

Answer 1

fibrinogen (factor I)
factor VIII
factor XIII 
von Willebrand factor
fibronectin

Question 2

What does fibronectin do in relation to hemostasis?

Answer 2

It is one of the components responsible for triggering platelet reactivity.

[From Harrison’s, 142: Arterial and Venous Thrombosis,
“The formation of a thrombus is initiated by the adherence of platelets to the damaged vessel wall. Damage exposes subendothelial components responsible for triggering platelet reactivity, including collagen, von Willebrand factor, fibronectin, and other adhesive proteins, such as vitronectin and thrombospondin”.]