Autoimmune Diseases

Question 1

What are the 5 features of CREST syndrome?

Answer 1

Calcinosis
Raynaud's phenomenon
Esophageal dysfunction
Sclerodactyly
Telangiectasia

Question 2

What are the four features of the American College of Rheumatology 1990 Criteria for the Classification of Henoch-Schönlein Purpura (HSP)?

Answer 2

1. ) Palpable purpura
2. ) Age less than or equal to 20 years at disease onset
3. ) Biopsy showing granulocytes around arterioles or venules
4. ) Gastrointestinal bleeding

(Source: Clinical Key, The American College of Rheumatology 1990 criteria for the classification of Henoch-Schönlein purpura.
Mills JA, Michel BA, Bloch DA, Calabrese LH, Hunder GG, Arend WP, Edworthy SM, Fauci AS, Leavitt RY, Lie JT - Arthritis Rheum. - August 1, 1990; 33 (8); 1114-21
MEDLINE is the source for the citation and abstract for this record.)

Question 3

The classic full presentation of Henoch-Schonlein purpura includes:

Answer 3

the acute onset of fever, palpable purpura on the lower extremities (Figure 39–1) and buttocks, abdominal pain, arthritis, and hematuria.
(from Current Diagnosis and Treatment: Rheumatology, Chapter 39)

Question 4

Henoch-Schönlein purpura (HSP) is the most common form of ________ __________ in children, with an annual incidence of ___ cases per million persons. The peak incidence is in the _____ ___ ______ decades of life (90% of patients are younger than __ _____ __ ___), with a male to female ratio of ___.

Answer 4

systemic vasculitis
140
first and second
10 years of age
2:1
(from Current Diagnosis and Treatment: Rheumatology, Chapter 39)

Question 5

What is the effect of hydroxychloroquine which makes it useful for treatingrheumatoid arthritis?

Answer 5

It inhibits locomotion of neutrophils and chemotaxis of eosinophils.

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