SARS-CoV-2 Pandemic

Question 1

What is thought to be the mechanism of action of hydroxychloroquine in the treatment of SARS-CoV-2 infected patients?

Answer 1

We propose that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients.

[From “In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)”, by Xueting Yao et al.]

Question 2

What is the SAVE score used for?

Answer 2

To assist prediction of survival for adult patients undergoing ECMO for refractory cardiogenic shock.
SAVE stands for Survival After Veno-arterial ECMO

Question 3

Where does the data that the SAVE score is based on come from?

Answer 3

Data was extracted from 2003 to 2013 from the ELSO registry (Extracorporeal Life Support Organization registry).

From “Predicting survival after ECMO for refractory cardiogenic shock: the survival after veno-arterial ECMO (SAVE) score

Question 4

What is the RESP score used for?

Answer 4

It was designed to predict survival for adult patients undergoing ECMO for respiratory failure (usually V-V ECMO).

Question 5

Where does the data that the RESP score is based on come from?

Answer 5

It comes from data extracted from 2000 to 2012 from the ELSO (Extracorporeal Life Support Organization) international registry.