Transfusion medicine Flashcards
What does an antibody screen test?
Detects significant blood group antibodies
If antibodies found, donor units lacking the corresponding antigen are identified prior to transfusion
What does a crossmatch test for?
Compatibility of recipient’s serum w/ donor RBCs
reconfirms ABO compatibility
- What is coombs antisera?
Antibodies against human antibodies (angi-human globulin) ; looking for Iggs
What is the universal plasma donor?
AB
What is the universal blood donor?
O
What is the antibody screening for “indirect coombs”
looks for antibodies in the patients PLASMA (that would only be there if they had been exposed to a transfusion before)
What should be performed when a AB screen is negative?
Rapid crossmatch
- What does a rapid crossmatch evaluate?
Confirms ABO compatibility between patient and donor
What type of immunoglobin can agglutinate by itself?
IgM
*What type of immunoglobin cannot agglutinate by itself?
IgG
you will need a coombs antisera to vause agglutination
- What is involved in the clinical decision of RBC transfusion?
Extent of RBC loss
- Rate and chronicity of red cell loss
- Oxygen requirement of the patient; state of tissue perfusion
- Response of the circulation to red cell loss and reinfusion
- Desired rate of restoration
At what hemoglobin level should a pt get a transfusion?
hemoglobin below 6 g/dL
What hemoglobin range does not indicate a necessary transfusion?
hemoglobin above 10 g/dL
What is the purpose of irradiation?
Prevents TA-GVHD (transfusion-associated graftvs host disease); impt in immunocompromised pts.
- What is the NL volume of plasma?
250-350 mL
