Myeloproliferative Disorders 9-26-14 Flashcards
*Define myeloproliferative disorder (neoplasms)
overproliferation of one more myeloid cell lineages
–>accumulation of
too many cells
Name 4 myeloproliferative disorder
- Chronic Myelogenous Leukemia
- Polycythemia Vera
- Essential Thrombocytosis
- Myelofibrosis
What are s/sx of myelogenous leukemia (CML)?
-Fatigue, Bleeding, Sweats, Weight Loss
Abdominal Fullness
-Purpura, Splenomegaly
Compare the 3 phases of CML
-Chronic Phase - median duration 3-5 years (85% of patients present
in chronic phase)
-Accelerated Phase - median duration 3-18 months
last Phase - median survival 3-6 months
- What is Tx for CML?
allogeneic hematopoietic stem cell transplant
- What disorder are Philadelphia chromosomes linked to?
CML
- What chromosome abnormality is the cause CML?
Fusion of chromosome 9 & 22
What is the Tx for CML?
Imatinib
What is the diagnostic criteria for polycythemia cera?
Hgb> 18.5 g/dl in M
>16.5 g/dl in F
-Presence of JAK2V617F
What is the onset age for Polycythemia vera (pv)?
60 yrs
What are s/sx of Polycythemia vera (PV)?
headache, dizziness, paresthesias,pruritus, splenomegaly, hepatomegaly
What is the Tx of Polycythemia Vera (PV)?
Phlebotomy (get rid of blood)
What is one complication of PV?
spent phase PV” (bone marrow burns out)–> pancytopenia
-20% tansform to acute myeloid leukemia
What is the onset age for Essential Thrombocythemia (ET)?
50-60
What is Tx of Essential Thrombocythemia (ET)?
hydroxyurea
