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PHARMA 3.0 > Toxicology > Flashcards

Toxicology Flashcards

0
Q

This herbicide attacts lung surfactant thus causing ARDS

A

Glycine. (glyphosate)

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1
Q

Most widely used herbicide in the world

A

Glycine

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2
Q

Herbicide known to cause true HL.

A

PCBs

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3
Q

Withe ndocrine disruptors, what type of cancer is associated with them?

A

BREAST and other reproductive cancers

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4
Q

This class of environmental pollutants are known to cause mimic enhance or inhibit a hormonal action.

A

Endocrine disruptors.

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5
Q

Phytoestrogens and mycoestrogens are classified as?

A

Endocrine disruptors.

Phytoestrogens- anti androgenic
Mycoestrogens

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6
Q

Give the three metalloids.

A

ABC

Asbestos
Berryllium
Cadmium

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7
Q

This herbicide is also known to cause YUSHO disease in Japan.

A

PCBs. Polychlorinated Biphenyls

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8
Q

This metalloid is known to cause chronic pulmonary fibrosis as an autoimmune attack on the skin and lungs

A

Berryllium

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9
Q

This metalloid most commonly causes lung cancer

A

Asbestos

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10
Q

This metalloid may also cause nephroblastom or renal failure

A

Cadmium

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11
Q

Name three heavy metals.

A

LAM

lead
Arsenic
Mercury

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12
Q

Oldest heavy metal occupational and environmental poison.

A

Lead

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13
Q

Give the route,

Industrial LEAD poisoning
Non-industrial LEAD poisoning

A

Industrial - respi

Non-industri - gastro

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14
Q

This type of lead is mainly found on paints, foods, drinks and industrial fumes

A

Inorganic lead

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15
Q

This lead is commonly used before as an antiknock additive in gasoline

A

Inorganic lead

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16
Q

Can be universally given if one does not know the name of poison as an antidote

A

IM DIMERCAPROL

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17
Q

This causes oliguric renal failure, hence hemoglobinuria

A

Organic arsenic

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18
Q

Used as an intravenous drug for inorganic lead poisoning

A

Calcium disodium edetate

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19
Q

This mettalloid mainly causes pneumonia or fibrosis in WELDERS.

A

Cadmium

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20
Q

Oral derivative of succinic acid used as antidote for inorganic lead poisoning

A

Succimer

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21
Q

Between types of arsenic, which cannot be treated with chelation

A

Organic arsenic.

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22
Q

Type of arsenic wherein which hemodialysis is the ultimate treatment

A

Organic arsenic

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23
Q

Aside from lead, this heavy metal can pr esent with basophilic stippling

A

Inorganic arsenic

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24
Q

Inorganic can be treated with UNITHIOL and DIMERCAPRIOL but ni oral form is available. T or F

A

True

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25
Q

Between the types of lead, skin exposure is poorly absorbed

A

Inorganic,

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26
Q

This heavy metal presents with raindrop hyperpigmentation of the skin

A

Inorganic arsenic

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27
Q

Give the triad for chronic mercury poisoning

A

NTG

neuropsych disturbances
tremor
gingivostomatitis

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28
Q

Erethism and acrodynia are common in what heavy metal poisoning.

A

Mercury

29
Q

Give the route of mercury absorption of the following types:

Elemental -
Organic -
Inorganic -

A

Inhalation
Inhalation, Ingestion
Percutaneous

30
Q

Universal antidote

A

Dimercaprol

31
Q

What heavy metal presents with ALDRICH-MEES lines?

A

Inorganic arsenic

32
Q

Used in iron overdose, oral form

A

Deferasirox

33
Q

What element is missing for patients with PD

A

Manganese. Give edta

34
Q

Used as iron chelator, intravenous form

A

Deferoxamine

35
Q

Used in cesium and thalium

A

Prussian blue

36
Q

Used for Wilson’s disease

A

Penicillamine

37
Q

Can be given for patients with Klinefelter rings

A

Penicillamine

38
Q

These are drugs that reverse the toxic effects of heavy metals or drugs by accelerating elimination.

A

Chelators

39
Q

For patients with megaloblastic anemia, what elements can be given

A

Co. B12

40
Q

What can be given in cases of cyanide poisoning.

A

Vit c. Converts cyanomethemoglobin to normal hemoglobin

41
Q

This element requires triple antidote consisting of vitamin c, b12 and nano2 or nas2so4

A

Cyanide

42
Q

Characterized as having bitter almond breathe. And can be due tomescessive cassava ingestion

A

Cyanide

43
Q

Can lavage be done to patient who ingested petroleum?

A

No. Corrosive

44
Q

Give drugs who are dopamine agonist

A

AN ACE

45
Q

Give drugs that are G protein coupled

A

Opiods
Cannabis
mescaline
GBH

46
Q

Drugs that are ionitropic

A

Ketamine

Bdz
Alcohol
Nictotine

47
Q

Drugs that are transporter of biogenic amines

A

ACE

amph
Cocaine
Ecatacy

48
Q

Alcohol dehydrogenase inhibitor

A

Fomepizole

49
Q

Avetalfehyde dehydrogenase inhibitor

A

Disulfiram

50
Q

For rehab treatment on alcoholism

A

Naltrexone

51
Q

GABA agonist but NMDA antagonist

A

Acamprosate

52
Q

Can be given to rekax muscles

A

Baclofen

53
Q

Given for delirium tremens

A

Topimarate

54
Q

Given in cessation of cigarette smoking but was then banned because of obesity

A

Rimonabant

55
Q

Commonly abused substance by health prof

A

Meperidine

56
Q

Causes visual disturbance as snow storm

A

Methanol

57
Q

Used as an antifreeze. Vision is normal

A

Ethylene glycol

58
Q

Characterized as with fomaldehyde breath

A

Methanol

59
Q

DOC for both methanol and ethylene

A

Ethanol

60
Q

Also known as ma huang

A

Meth

61
Q

True or false. Both methylene and ethylene cause met acidosis

A

True

62
Q

Heroine is characterized with nasal perforation.

A

True

63
Q

This drug is characterized as having blood shot eyes.

A

Marijuana

64
Q

This drug causes an increase in apetite

A

Marijuana

65
Q

Give the blood alcohol level and their clinical effects.

A

SAECD

50-100 --- sedation
100-200 ---- ataxia
200-300 ---- emesis, stupor
300-400 ---- coma 
>500 --- death
66
Q

When does delirium tremens appeaR?

A

After 3-4 days of alcohol withdrawal.

67
Q

What subs causes pulmo fibrosis

A

PBB

Paraquat, bleomycin, busulfan

68
Q

What cause hepatic necrosis

A

Acetaminophen, 14tabs plus

Mushroom

69
Q

Drug for watusi

A

Acetaminophen
Phytonadione
Cal gluc

70
Q

Acute alcohol overdoze

A

Naloxone

71
Q

BDZ antidote

A

Flumazenil

PHARMA 3.0 (7 decks)

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