Anti-virals

Question 0

Oral nucleoside analogs for VZV and HSV

Answer 0

Acyclo, Valacyclo, Famciclovir

Question 1

Of the drug against HSV and VZV which is available in intravenous form?

Answer 1

Acyclovir

Question 2

Oral nucleoside analogs for VZV and HSV are all well tolerated?

Answer 2

True

Question 3

Acycline guanosine derivative

Answer 3

Acyclovir

Question 4

Acts BOTH as a chain terminator and substrate

Answer 4

TRUE. Lacks 3’OH

Question 5

More than half of HSV strains are TK negative strains.

Answer 5

True

Question 6

What causes R in acyclovir

Answer 6

Changes in DNA polymerase

Decreased TK activity

Question 7

True or false. Acyclovir can be used prophylacticslly in immunocompromised patients

Answer 7

True, undergoing BMT and transplant

Question 8

Acyclovir is HEMATOTOXIC

Answer 8

false, NOT HEMATOTOXIC

Question 9

Ester of acyclovir

Answer 9

Valacyclovir

Question 10

Among acyclovir and valacylovir, which decreased post herpetic pain?

Answer 10

Valacyclovir

Question 11

Between valacyclovir and acyclovir, which has higher bioavialability in the CSF

Answer 11

Valacyclovir

Question 12

In patients having crystalluria dt acyclovir, what must be dine

Answer 12

Increase hydration

Question 13

How many phosphorylation must occur to activate antiviral agents

Answer 13

3

Question 14

Valacyclovir undergo first pass metabolism

Answer 14

True

Question 15

This causes DNA polymerase inhibition but cannot lead to chain termination because of the presence of 3’OH group

Answer 15

Famciclovir

Question 16

Its prodrug is famciclovir

Answer 16

Penciclovir

Question 17

It is a topocal cream that prevents the fusion between HSV and host cell thus preventing viral entry

Answer 17

Doconasol

Question 18

This antiviral agent against HSV 1 and 2 has not been used because it competes for DNA incorporation both on human and viral DNA

Answer 18

Trifluridine

Question 19

Trifluridine acts where?

Answer 19

Acts on the thrird phosphorylation with thymidine triphosphate for incorporation into the DNA.

Question 20

New drig for EBV

Answer 20

Valomacyclovir

Question 21

Same mechanism of acyclovir but acts in CMV and is not thymidine kinase dependent but phosphotransferase dependent which is also viral dependent?

Answer 21

Ganciclovir

Question 22

Ganciclor which act on what virus, causes both chain termination and inhibition of viral DNA polymerase.

Answer 22

CMV — true

Question 23

Can be used for HSV, VZV and CMV

Answer 23

Ganciclovir

Question 24

Resistance is due to the absence of phosphotransferases

Answer 24

Ganciclovir

Question 25

This antiviral drug causes HEMATOTOXICITY

Answer 25

ganciclovir

Question 26

This antiviral drug has similar indication as that of gancivlovir (hsv, vzv, cmv) but is not dependent on phosphotransferases

Answer 26

Foscarnet

Question 27

This drug undergoes viral independent phosphorylation

Answer 27

Foscarnet

Question 28

MOA is that it prevents the binding of thymidine triphosphate to the DNA. Rather, blocks the pyrophosphate binding sites

Answer 28

Foscarnet

Question 29

Can be used for acyclovir resistant strains if HSV which are TK negative

Answer 29

Foscarnet

Question 30

What drug must not be given to patients having FOSCARNET

Answer 30

Pentamidine (hypocalcemia) and Ampho B and Aminoglycosides (nephrotoxic)

Question 31

Acts as both substarte and inhibitor and has viral independent phosphorylation

Answer 31

Cidofovir

Question 32

For CMV and HSV altered strain, and TK negative

Answer 32

Cidoforvir

Question 33

Used in intraocular implant

Answer 33

Ganciclovir

Question 34

Antiretroviral drug that competitively inhibts HIV reverse transcriptase and causes chain termination

Answer 34

NRTI

Question 35

This drug causes mitochondrial toxicity via DNA polymerase gamma

Answer 35

NRTI

Question 36

Fatal event with NRTI

Answer 36

Hepatic steatosis

Question 37

What must be monitored in givinig patients with NRTI?

Answer 37

Liver fxn tests

Question 38

Prototype of NRTI

Answer 38

Zidovudine

Question 39

What must ne monitored when giving AZT because it causes toxicity

Answer 39

CAPAS ``` cimetidine Aspirin Probenecid Acetaminophen Sulfonamides ```

Question 40

Together with ganciclovir, what other drug is also dose dependetly HEMATOTOXIC and causes severe peripheral neuropathy

Answer 40

AZT

Question 41

Lipid metabolism apis affected with what antiretroviral

Answer 41

NRTI

Question 42

Didanosine commonly causes pancreatitis, and typical NRTI

Answer 42

Pancreatitis

Question 43

This antiretroviral drug has been said to be effective for hepa b

Answer 43

Lamivudine

Question 44

This antriretroviral binds directly to the viral DNA polymerase. Doesnt require phosphorylation nor comeptes

Answer 44

NNRTI

Question 45

Side effect NNRTI

Answer 45

SJS, GIT

Question 46

Metabolized by CYP450

Answer 46

NNRTI

Question 47

SaMPLE NNRTI

Answer 47

Efavirenz. Nevirapine

Question 48

This antiretroviral has side effect of fat redistribution

Answer 48

Protease INhibitor

Question 49

Inhibitor for cyp3a4

Answer 49

PI

Question 50

Ritonavir is an example of a protease inhibitor

Answer 50

Trie

Question 51

Antoretroviral that causes insulin resistance

Answer 51

PI

Question 52

With must be looked upon with ritonavir?i

Answer 52

Ncreased effect of dronabinol, eruthro, ketoconazole and rifampin KERD

Question 53

Fusion inhibitor approved for HIV

Answer 53

Maraviroc

Question 54

Fustion inhibitor attaching to the gp41 preveting conformational change

Answer 54

Enfuviride

Question 55

Fusion inhibitor that needs tropism testinf

Answer 55

Maraviroc

Question 56

FI that is for NNRi and NRTI resistanr

Answer 56

Maraviroc

Question 57

Integrase inhibitor

Answer 57

Raltegravir

Question 58

Inhibits strand transfer which is the final step in provirus

Answer 58

Raltegravir

Question 59

Pyriminidone analog

Answer 59

Raltegravir

Question 60

Known as the triple drug regimen

Answer 60

HAARY

Question 61

Moa of HAART

Answer 61

Decrease viral mrna. Decrease opp infxns. Reverse decline in cd4

Question 62

A- azt B- NRTI C- PI and NNRTI

Answer 62

HAART

Question 63

Give anti hepatitis agnets

Answer 63

HEPA LA REIN ``` lamivudine Adefovir Ribavirin Entecavir Interferon alpha 2b ```

Question 64

FIbthat is given SQ

Answer 64

Enfuvirtide

Question 65

AH used for both HBV and HBC

Answer 65

Interf

Question 66

Uncoating blocking agents

Answer 66

Amantadine and rimantadine

Question 67

Blocks m2 proton ion channel of the virus

Answer 67

Amantadine

Question 68

Amantadine and rimantadine are for influenza A only

Answer 68

True

Question 69

Shows no cross resistance in neuramindase inhibitors

Answer 69

Amantadine

Question 70

Rimantadine requores renal dose adjustment

Answer 70

True

Question 71

Analogs of sialic acid

Answer 71

Neuraminidase inhibitor, zanamavir, olsetamavir

Question 72

Has activibity for both influenza a and b

Answer 72

Zanamavir - inhalation | and oseltamavir - oral

Question 73

Drug for kamivudine resistant strain HBV

Answer 73

Adefovor

Question 74

For HBV with 100 BA

Answer 74

Entecavir

Question 75

For hCV not allowed in renal prob

Answer 75

Ribavirin