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PHARMA 3.0 > TB Drugs > Flashcards

TB Drugs Flashcards

0
Q

This is not given to children below 6

A

Ethambutol

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1
Q

What drug/s is/are used for prophylaxis on AIDS patient to prevent TB

A

Azithro or clarithro

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2
Q

Among RIPES which must have no dose adjustment in cases of renal insuff

A

RIP

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3
Q

Anti TB DRUGS are effective at what phase of the bacteria

A

Replication

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4
Q

What virulence factor of TB decreases the permeability of drug

A

Mycolic Acid

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5
Q

This drug’s MOA is the inhibition of mycolic acid

A

INH

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6
Q

Among all anti TB drug which is considered a prodrug

A

INH and PZA

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7
Q

For INH to be active what must activate it

A

KatG which is a mycobacterial catalase-peroxidase by the bacteria

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8
Q

If the KatG gene is lost what type of resistance happen

A

High

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9
Q

What drug must be looked into when giving INH since this might increase its conx

A

Phenytoin and carbamazepine

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10
Q

Common side effect of INH

A

Hepatitis - age dependent
Peripheral neuritis
SLE - rare

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11
Q

With high level of resistance, is there cross resistance with ethionamide

A

None.

Low - YES.

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12
Q

What type of resistance is there when there is a change in inhA gene

A

Low type. Resistance present.

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13
Q

Other drugs causing SLE

A

Hydralazine
Pyrazinamide
Isoniazid

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14
Q

MOA of rifampicin

A

Inhibits RNA synthesis

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15
Q

Can be used for meningitis together with azithro and vancomycin

A

Rifampin

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16
Q

Can be used for leprosy

A

Rifampin

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17
Q

Used as prophylaxis for influenza

A

Rifampin

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18
Q

Common side effects of rifampin

A

Anemia. Thrombocytopenia. Red orange secretions. FLU LIKE s/sx

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19
Q

Among TB drugs which are enzyme inducers

A

Rifampin

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20
Q

Prevents binding to RNA polymerase is who’s MOA

A

Rifampin

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21
Q

What drug must be protected from light

A

Rip

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22
Q

Induces cyp450

A

Rif

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23
Q

Relatie of nicotinamaide

A

Pza

24
Q

Disrupts mycobcterial cell membrane metab and cell transport

A

Pza

25
Q

Pza is Converted to pyrazinoic acid by

A

Pyrazinamidase

26
Q

It is known as a sterilizing agent

A

Pza

27
Q

Must not be given to pts with gout

A

Pza

28
Q

Must not be given to pts with porphyria

A

Pza

29
Q

Must not be given to pts with arthralgia

A

Pza

30
Q

This drug is important because it inhibits the formation of an essential component needed for the mycobcterial cell wall

A

Ethambutol. Arabinoglycan. Arabinosyl transferase

31
Q

It causes retrobulbar neuritis

A

Ethambutol. Dose dependent

32
Q

What drug must have reduced dose for pts with renal insuff

A

Ethambutol and Streptomycin

33
Q

When emb gene is mutated, what drug is affected

A

Ethambutol

34
Q

Irreversible inhibitor of protein synthesis

A

Stre

35
Q

Among Ripes, which acts both intra and extra

A

IE

R- not mentioned
P- intra
S - extra

36
Q

IRE is only available to lactating and pregnant moms

A

True

37
Q

Para aminosalicyclic acid cannot be used to pregnant

A

False. Sfe but poorly tolerated

38
Q

Doc for MAC

A

Ethambutol PLUS rifam OR cipro PLUS azithro or clarithro

39
Q

Used for MAC propy

A

Azithro OR clarithro

40
Q

For m. Kansaii

A

IRE

41
Q

Effective for lepromatous leprosy

A

Rifampin

42
Q

Doc for leprosy

A

Dapsone

43
Q

In cases of sulfone resistance what can be given

A

Clofazimine

44
Q

What can be used as a clue that the patient is having clofazimine

A

Skin discoloration from res brown to black

45
Q

2 drugs that can be given for erythema nodosum leprosum

A

Prednisone and Thalidomide

46
Q

This anti leprosy drug causes erythema nodosum

A

Dapaone

47
Q

Skin rash as major SE

A

Any drug esp strep

48
Q

Causes ototox

A

Strep

49
Q

Causes jaundice due to hepatitis

A

RIP

50
Q

Causes psychosis and convulsion

A

Isoniazid

51
Q

Thrombocytopenia and anemia

A

Rifamp

52
Q

Oliguttia or albuminuria

A

RS

53
Q

If patient drinking P had arthralgia due to hyperuricemia what must be done

A

Give nsaid

54
Q

For pts havin flu lile symptoms with rifam should the drug be dc

A

No

55
Q

If patient had GI intolerance what must be done

A

Give at bedtime

56
Q

Regimen 1 - new patient

A

2 RIPE

4 RI

57
Q

Regimen 2 - relapse

A

2 RIPES
1 RIPE
5 IRE

PHARMA 3.0 (7 decks)

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