TB Drugs

Question 0

This is not given to children below 6

Answer 0

Ethambutol

Question 1

What drug/s is/are used for prophylaxis on AIDS patient to prevent TB

Answer 1

Azithro or clarithro

Question 2

Among RIPES which must have no dose adjustment in cases of renal insuff

Answer 2

RIP

Question 3

Anti TB DRUGS are effective at what phase of the bacteria

Answer 3

Replication

Question 4

What virulence factor of TB decreases the permeability of drug

Answer 4

Mycolic Acid

Question 5

This drug’s MOA is the inhibition of mycolic acid

Answer 5

INH

Question 6

Among all anti TB drug which is considered a prodrug

Answer 6

INH and PZA

Question 7

For INH to be active what must activate it

Answer 7

KatG which is a mycobacterial catalase-peroxidase by the bacteria

Question 8

If the KatG gene is lost what type of resistance happen

Answer 8

High

Question 9

What drug must be looked into when giving INH since this might increase its conx

Answer 9

Phenytoin and carbamazepine

Question 10

Common side effect of INH

Answer 10

Hepatitis - age dependent
Peripheral neuritis
SLE - rare

Question 11

With high level of resistance, is there cross resistance with ethionamide

Answer 11

None.

Low - YES.

Question 12

What type of resistance is there when there is a change in inhA gene

Answer 12

Low type. Resistance present.

Question 13

Other drugs causing SLE

Answer 13

Hydralazine
Pyrazinamide
Isoniazid

Question 14

MOA of rifampicin

Answer 14

Inhibits RNA synthesis

Question 15

Can be used for meningitis together with azithro and vancomycin

Answer 15

Rifampin

Question 16

Can be used for leprosy

Answer 16

Rifampin

Question 17

Used as prophylaxis for influenza

Answer 17

Rifampin

Question 18

Common side effects of rifampin

Answer 18

Anemia. Thrombocytopenia. Red orange secretions. FLU LIKE s/sx

Question 19

Among TB drugs which are enzyme inducers

Answer 19

Rifampin

Question 20

Prevents binding to RNA polymerase is who’s MOA

Answer 20

Rifampin

Question 21

What drug must be protected from light

Answer 21

Rip

Question 22

Induces cyp450

Answer 22

Rif

Question 23

Relatie of nicotinamaide

Answer 23

Pza

Question 24

Disrupts mycobcterial cell membrane metab and cell transport

Answer 24

Pza

Question 25

Pza is Converted to pyrazinoic acid by

Answer 25

Pyrazinamidase

Question 26

It is known as a sterilizing agent

Answer 26

Pza

Question 27

Must not be given to pts with gout

Answer 27

Pza

Question 28

Must not be given to pts with porphyria

Answer 28

Pza

Question 29

Must not be given to pts with arthralgia

Answer 29

Pza

Question 30

This drug is important because it inhibits the formation of an essential component needed for the mycobcterial cell wall

Answer 30

Ethambutol. Arabinoglycan. Arabinosyl transferase

Question 31

It causes retrobulbar neuritis

Answer 31

Ethambutol. Dose dependent

Question 32

What drug must have reduced dose for pts with renal insuff

Answer 32

Ethambutol and Streptomycin

Question 33

When emb gene is mutated, what drug is affected

Answer 33

Ethambutol

Question 34

Irreversible inhibitor of protein synthesis

Answer 34

Stre

Question 35

Among Ripes, which acts both intra and extra

Answer 35

IE R- not mentioned P- intra S - extra

Question 36

IRE is only available to lactating and pregnant moms

Answer 36

True

Question 37

Para aminosalicyclic acid cannot be used to pregnant

Answer 37

False. Sfe but poorly tolerated

Question 38

Doc for MAC

Answer 38

Ethambutol PLUS rifam OR cipro PLUS azithro or clarithro

Question 39

Used for MAC propy

Answer 39

Azithro OR clarithro

Question 40

For m. Kansaii

Answer 40

IRE

Question 41

Effective for lepromatous leprosy

Answer 41

Rifampin

Question 42

Doc for leprosy

Answer 42

Dapsone

Question 43

In cases of sulfone resistance what can be given

Answer 43

Clofazimine

Question 44

What can be used as a clue that the patient is having clofazimine

Answer 44

Skin discoloration from res brown to black

Question 45

2 drugs that can be given for erythema nodosum leprosum

Answer 45

Prednisone and Thalidomide

Question 46

This anti leprosy drug causes erythema nodosum

Answer 46

Dapaone

Question 47

Skin rash as major SE

Answer 47

Any drug esp strep

Question 48

Causes ototox

Answer 48

Strep

Question 49

Causes jaundice due to hepatitis

Answer 49

RIP

Question 50

Causes psychosis and convulsion

Answer 50

Isoniazid

Question 51

Thrombocytopenia and anemia

Answer 51

Rifamp

Question 52

Oliguttia or albuminuria

Answer 52

RS

Question 53

If patient drinking P had arthralgia due to hyperuricemia what must be done

Answer 53

Give nsaid

Question 54

For pts havin flu lile symptoms with rifam should the drug be dc

Answer 54

No

Question 55

If patient had GI intolerance what must be done

Answer 55

Give at bedtime

Question 56

Regimen 1 - new patient

Answer 56

2 RIPE | 4 RI

Question 57

Regimen 2 - relapse

Answer 57

2 RIPES 1 RIPE 5 IRE