Anti-fungal Flashcards
Give the property of ampho that makes it insoluble in water
Lipid
True or false. Amphotericin B cannot be used for systemic diseases since it is poorly absorbed in the GIT but categorized as systemic antifungal
Ampho B
Mde of acrion is that it creates pores in the cell membrane
Ampho B
This antifungal drug has the broadest spectrum of action
Ampho B
True or false. DOSE must be ADJUST during hepatic and renal impairment
No, it cannot be absorbed systematically. Localized in the GIT only.
This is used as part of an initial therapy to decrease fungal burden
Ampho B
This causes the toxicity associated with ampho B
Some strains bind to human cholesterol
Give examples of condition requiring localized treatment with Ampho B.
Bladder wash out. Local infiltration in fungal arthritis, corneal ulcers.
What is the effect of cumulative toxicity in ampho B
Renal damage
End point of induction therapy for ampho b
1-2g
Cumulative toxicity level of ampho b
> 4 g
Adverse effect asso with ampho b is called infusion related toxicity, what should the management be?
Symptomatic treatment.
Do premeditation.
A pyrimidine fungal analog.
Flucytosine
Narrow spectrum compared to ampho?
Flucytosine
Ampho can be used for cryptococcal meng?
False. Cannot extensively cross BBB. 2-3%
Can effectively cross BBB thus used for cryptococcal meningitis
Flucytosine and FLUCONAZOLE
This antifungal inhibits both RNA and DNA synthesis
Flucytosine
What enzyme is needed for 5FC to be taken up by fungal cells
Cytosine permease
True or false. Ampho has good synergy with 5FC
True- cryp meng
Itraconazole plus 5fc can be used for.
Chromoblastomycosis
Adverse effect of 5FC
Bone marrow depression.
Remember, it has been considered as an antineoplastic nut proven to be not.
This antifungal drug is used to inhibit ergosterol synthesis
Azoles
Through what mechanism can azoles inhibit ergosterol synthesis
- inhibition of fungal cyp450
- demethylation of lanosterol (precursor)
Precursor of ergosterol
Lanosterol
