Toxicology Flashcards
Xenobiotic
Substances that are foreign to the body
Mode of ingestion
How a substance enters the body
LD 50
Lethal dose for 50% of the population
Opiates
Drugs obtained from opium
ADME
Absorption
Distribution
Metabolism
Excretion
(The process by which drugs and toxins move through the body)
C sub p
Peak plasma concentration
First-pass metabolism
Reduces concentration of a drug in the bloodstream; affects orally ingested drugs
Metabolites
Substance made or used when the body breaks down drugs
Central blood
Blood sample taken from the heart
Peripheral blood
Blood sample taken from a site away from the heart
Postmortem distribution
The concentration of toxins and metabolites can change after death
Immunoassays
Screening test based on the reaction between antigens and antibodies
Mass spectrometry
Measures the mass of a molecule after it converts the molecule to a gas-phase ion