Total Review

Question 1

this type of tablet is useful when administering large tablets to children

Answer 1

chewable tablets

Question 2

How to avoid moisture in gelatin capsules?

Answer 2

small desiccant materials can be used to protect against absorption of atmospheric moisture

Question 3

What is produced in effervescent tablets when it comes in contact with water?
What is its role?

Answer 3

CO2 (between sodium bicarbonate and organic acids)
CO2 acts as disintegrator and produces effervescent effects

Question 4

A

Answer 4

A is immediate release

Question 5

B

Answer 5

B is delayed

Question 6

C

Answer 6

C is repeat

Question 7

D

Answer 7

D is extended

Question 8

what is therapeutic index?
how is it relevant in design of sustained release formulations?

Answer 8

TI =LD50/ED50

a drug is considered to be safe if its TI> 10

Drugs with low TI are not suitable for extended release formulation due to risk of dose dumping or burst release

Question 9

What level is safe for modified release?

Answer 9

needs to be over 10

Question 10

What are advantages of solid dosage form over liquid form?

Answer 10

more exact dose (accurate)
more stable
easy shipping and handling
less needed shelf space
more easy to mask taste

Question 11

T/F
Deflocculated suspension is associated with attraction forces > repulsion forces

Answer 11

False

Question 12

What are the advantages of granules over powders?

Answer 12

Moves easier (flows better)
increase compressibility
also eliminate or control dust
segregation of the constituents of the powder mixture could be avoided by granulation
granules have lower surface area compared to powder of equal amount (improved stability by reducing exposure to environment)

Question 13

What type of tablets are designed for absorption through the oral mucosa?

Answer 13

buccal or sublingual tablets

Question 14

What is the method of preparation of carbomer gel?

Answer 14

prepare carbomer dispersion
adjust the pH (6-11, neutral is better)

Question 15

What are the differences between orally disintegrating tablets and chewable tablets?

Answer 15

one needs the disintegrating agents
one is being disintegrated mechanically (chewing)

ODT should disintegrate and dissolves in the mouth without water within 60 seconds or less
ODT no chewing is needed
ODT requires disintegrating agents

Question 16

Which of the following is not true for hard gelatin capsules?
A) disintegrants are used in capsules for faster dissolution
B) water soluble drugs are dispensed in the capsules
C) can only be administered via oral route
D) easily mask the taste of the drug

Answer 16

C is false (vaginal/rectal)

Question 17

What are the two types of diffusion systems for controlled release formulations?

Answer 17

reservoir devices (core is surrounded by polymeric membrane)
matrix device (dissolved or dispersed drug is distributed uniformly in an inert polymeric matrix)

Question 18

What are the advantages of using alcohol as co-solvent?

Answer 18

antimicrobal
better solubility for many compounds
better stability for the drug
- decrease hydrolysis
- decrease bacterial growth (10-12% will have preservative)

Question 19

WHy drugs with a half life of less than 2 hours are not good candidates for sustained release formulation?

Answer 19

It will require large dose to continued being productive

Question 20

what is the mechanism of disintegration enteric coated tablets?

Answer 20

They are depend on ph increase along with GIT and then the coating will expands, dissolves and allows gastric fluids and disintegrates (need to be basic for the coating to break down)

Question 21

What are the advantages of suspensions over solid dosage forms?

Answer 21

better to give for children (anyone with problems swallow)
more rapid absorption of suspended particles
easy to swallow
enables easy administration of bulk insoluble powders

Question 22

What are the three steps for a drug to be processed in the body that is changed based on formulation?

Answer 22

disintegration
dissolution
absorption

Question 23

In relation to suspensions, which of the following statements in correct?
the taste of many drugs is more noticable in suspension that in solution
a suspension is a liquid preparation containing one or more APIs dissolved in a suitable vehicles

Answer 23

the first is true as solution is dissolved already and in order to taste it needs to be dissolved by the tongue

the second –> it is not disolved it is dispered

Question 24

Suspensions are not permitted to show sedimentation on standing

Answer 24

yes as long as it is reversible (by shaking)

Question 25

Suspension are examples of stabilized oil in water dispersions

Answer 25

false –> emulsions is what they are talking about (oil in water)

Question 26

suspensions are useful for administering insoluble or poorly water soluble drugs

Answer 26

yes

Question 27

When can weight variation test be used to estimate drug content uniformity?

Answer 27

When the product to be tested contains 50 mg or more of an active ingredient comprising 50% or more by weight of the dosage form unit

Question 28

What are some causes of lamination/capping?

Answer 28

air entrapment in light and fluffy powders
excessive fines
too little moisture in granulation
weak granules or too weak a binder
improper adjustment of machinery