MRDF Flashcards
Based on the conventional release profile, what are the challenges you identify for drug action?
conventional dosage forms do not maintain blood concentration within therapeutic range for extended period of time and
controllable drug release is not possible
What does MEC?
minium effective concentration
What is MTC?
Minimum toxic concentration
if drug level have to be maintained using conventional dosage forms what are the two approaches?
increase initial dose to increase duration of actions
administer the drug repeatedly using a constant dosing interval
What is the consequence of increasing initial dose?
increase potential of toxicity
What is the consequence of repeated drug administration
missed doses or
made up doses or
pt non-compliance
What is the rationale for MRDFs?
to prolong or control drug availability or release with the intent of improving efficacy of drug therapy
What is the two major types of MRDFs?
delayed action
extended action
Define delayed action
lag period between admin. and release
release the drug at particular site
mostly enteric coated
Define extended action
release the medication in a controlled manner at a predetermined rate, duration and location to achieve and maintain therapeutic blood levels
What does sustained release systems include?
any drug delivery system that achieves slow release of drug over extended period of time
What is needed to consider it a controlled release system?
if a sustained release system is successful at maintaining constant drug levels in the target organs
What is needed to consider it a prolonged release system?
prolongs therapeutic levels of the drugs
What is the purpose of extended release systems?
allows reduction in dosing frequency
What is the purpose of delayed release systems?
it can release the drug at a time other than promptly after administration
Define targeted release
isolates or contrates the drugs in specific body region, tissue or organ
What is an example of targeted release?
tumor nanomedicine - targeted drug delivery
what is repeat action?
forms usually contain two or more single doses of the drug, one for immediate release and the second for delayed release
What are the examples for preparing delayed action formulation?
entric coated
rheumatoid action
morning sickness
What is the rationale for extended release?
provides an immediate release, giving the effect now as well as by the gradual and continual release of additional amounts of drug
T/F Controlled release are therefore extended release formulations
True
What is the difference between SR and XL?
it is different in the duration of action
List somes advantages of MRDFs
less fluctuation of drug levels
reduced dosing frequency
enhanced pt compliance
reduction in A/E
reduced in health care cost