TORCH

Question 1

what does TORCH stand for?

Answer 1

Toxoplasmosis
Other (syphilis, zika)
Rubella
Cytomegalovirus
Herpes simplex virus

Question 2

what should we screen pregnant women for at their first prenatal visit? (3)

Answer 2

syphilis
rubella
varicella

Question 3

7 yo child presents with chorioretinitis, hydrocephalus, and intracranial calcifications. Dx? treatment?

Answer 3

toxoplasmosis

pyrimethamine

Question 4

patient presents with placental and umbilical cord abnormalities, hepatomegaly, rhinitis (snuffles), and a maculopapular rash. Dx? treatment?

Answer 4

congenital syphilis
parenteral penicillin

Question 5

what are 2 presentations of late congenital syphilis

Answer 5

hutchinson’s teeth
saddle nose

Question 6

how does maternal-fetal transmission of rubella virus occur?

Answer 6

hematogenous spread

Question 7

during which trimester is acquirement of rubella the worst?

Answer 7

1st trimester

Question 8

encompasses all outcomes associated with intrauterine rubella infection; severity secondary to when mom got rubella

Answer 8

congenital rubella infection

Question 9

presents with a constellation of birth defects due to rubella

Answer 9

congenital rubella syndrome

Question 10

baby presents with purpuric skin lesions described as blueberry muffin lesions, cataracts, cardiac malformations, growth retardation, and bone disease. Dx? treatment?

Answer 10

congenital rubella syndrome

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Question 11

what is the most important aspect of management of congenital rubella infection?

Answer 11

prevention

Question 12

children with CRS are considered to be contagious until what age?

Answer 12

1 year

Question 13

CMV presentation in mother and child are usually _____

Answer 13

asymptomatic

Question 14

what is the most common congenital viral infection?

Answer 14

CMV

Question 15

maternal CMV infection during pregnancy most often results from close contact with what?

Answer 15

children attending daycare centers

Question 16

what is the diagnostic used for CMV?

Answer 16

molecular detection of urine or saliva

Question 17

when is HSV transmitted to an infant?

Answer 17

during birth

Question 18

what are the 3 patterns in which perinatally acquired HSV develops?

Answer 18

localized to skin, eyes, mouth
localized CNS
disseminated involving multiple organs

Question 19

how does perinatally acquired HSV present?

Answer 19

non-specific

temp instability
respiratory distress
poor feeding
lethargy
hypotension
jaundice

Question 20

newborn presents with skin vesicles, ulcerations, and scarring, with eye damage and microcephaly or hydranencephaly. Dx?

Answer 20

congenital (in utero) HSV

Question 21

what is the treatment for perinatally acquired and congenital HSV?

Answer 21

acyclovir

Question 22

child presents with severe microcephaly with partially collapsed skull, thin cerebral cortices with subcortical calcifications, macular scarring and focal pigmentary retinal mottling, and congenital contractures. Dx? treatment?

Answer 22

Zika

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