Topoisomerase inhibitors

Question 1

Name the 2 epipodophyllotoxin topoisomerase inhibitors….

Answer 1

Etoposide

Teniposide

Question 2

What do the epipodophyllotoxins Etoposide and Tenisposide inhibit?

Answer 2

Inhibit topoisomerase II

Question 3

Etoposide is used for the treatment of….

Answer 3

Testicular carcinoma
lung cancer
non-Hodgkin’s lymphoma

Question 4

Teniposide is used for the treatment of….

Answer 4

ALL

Question 5

Epipodophyllotoxins–Etoposide and Teniposide have the same side effects, what are they?

Answer 5

Dose-limiting myelosuppression–neutropenia

Oral mucositis

Question 6

Name the Camptothecin analog topoisomerase inhibitors…

Answer 6

Irinotecan

Topotecan

Question 7

What to the Camptothecin analogs, Irinotecan and Topotecan inhibit?

Answer 7

Topoisomerase I

Question 8

What class are Irinotecan and topotecan topoisomerase inhibitors in?

Answer 8

Camptothecin analog

Question 9

Irinotecan a topoisomerase inhibitor is used in the treatment of….

Answer 9

Advanced colorectal cancer

lung, ovarian, cervical and brain tumors

Question 10

Topotecan, a topoisomerase inhibitor is used in the treatment of….

Answer 10

Ovarian and small cell lung cancer

Question 11

What are the side effects of the camptothecin analog topoisomerase inhibitors Irinotecan and Topotecan?

Answer 11

Severe neutropenia

Severe Diarrhea