Hormone Therapy

Question 1

What is the hormone therapy used for?

Answer 1

Treatment of hormone-dependent neoplasms

Question 2

Name the two Glucocorticoids used for hormone therapy…

Answer 2

Prednisone

Dexamethasone

Question 3

The glucocorticoids, prednisone and dexamethasone treat hormone-dependent neoplasms through the inhibition of what?

Answer 3

mitosis of lymphocytes

Question 4

Prednisone is used in combination therapy of what cancers?

Answer 4

Hodgkin’s and non-hodgkin’s
Multiple myeloma
CLL

Question 5

Prednisone is used for the treatment of….

Answer 5

ALL

Question 6

What does Dexamethasone do when using it for hormone therapy?

Answer 6

reduces edema in brain and spinal cord tumors with radiation therapy

Question 7

Name the selective estrogen receptor modulator used for hormone therapy…

Answer 7

Tamoxifen

Question 8

What is the mechanism for Tamoxifen?

Answer 8

Competes with estradiol for binding to estrogen receptor

Question 9

Used for hormone therapy in ER-positive breast cancer, or as adjuvant therapy following primary breast tumor excision–prevention of breast cancer in high-risk patients?

Answer 9

Tamoxifen

Question 10

What are the side effects of Tamoxifen?

Answer 10

Hot flushes
Hair loss
N/V

Question 11

Patients who are put on Tamoxifen are at an increased risk of developing what?

Answer 11

Endometrial cancer

thromboembolic event

Question 12

Name the selective estrogen receptor down regulator used for hormone therapy…

Answer 12

Fulvestrant

Question 13

What is the mechanism of action for Fulvestrant?

Answer 13

Binds with much higher affinity to estrogen receptor than tamoxifen–inhibits dimerization which increases degradation and reduces the overall ER level

Question 14

Used in postmenopausal women with ER-positive metastatic breast cancer…

Answer 14

Fulvestrant

Question 15

Name the 4 Aromatase inhibitors used for hormone therapy…

Answer 15

Aminoglutethamide
Anastrozole
Letrozole
Exemestane

Question 16

A relatively weak hormone therapy arrogates inhibitor used for breast cancer treatment…

Answer 16

Aminoglutethamide

Question 17

First-line for ER-positive breast cancer in postmenopausal women…

Answer 17

Anastrozole

Question 18

Letrozole and Exemestane are arrogates inhibitors used in hormone therapy. What are they used to treat?

Answer 18

ER-postive breast cancer in postmenopausal women

Question 19

Name the two GnRH analogs used for Hormone therapy…

Answer 19

Leuprolide

Goserelin

Question 20

What is the mechanism of action for the GnRH analogs Leuprolide and Goserelin used in hormone therapy?

Answer 20

Binds GnRH receptor–inhibits release of FSH and LH

Question 21

Leuprolide and Goserelin, GnRH analogs used in hormone therapy, are used to treat what?

Answer 21

Androgen ablation therapy, along with AR blockers

Question 22

Name the non steroidal androgen-receptor blockers used for hormone therapy…

Answer 22

Flutamide

Bicalutamide

Question 23

What is the mechanism of action for Fluamide and Bicalutamide?

Answer 23

Competes with androgen for AR binding

Question 24

What is Flutamide and Bicalutamide, non steroidal androgen-receptor blockers used for?

Answer 24

Androgen ablation therapy, along with GnRH analogs