Hormone Therapy Flashcards
What is the hormone therapy used for?
Treatment of hormone-dependent neoplasms
Name the two Glucocorticoids used for hormone therapy…
Prednisone
Dexamethasone
The glucocorticoids, prednisone and dexamethasone treat hormone-dependent neoplasms through the inhibition of what?
mitosis of lymphocytes
Prednisone is used in combination therapy of what cancers?
Hodgkin’s and non-hodgkin’s
Multiple myeloma
CLL
Prednisone is used for the treatment of….
ALL
What does Dexamethasone do when using it for hormone therapy?
reduces edema in brain and spinal cord tumors with radiation therapy
Name the selective estrogen receptor modulator used for hormone therapy…
Tamoxifen
What is the mechanism for Tamoxifen?
Competes with estradiol for binding to estrogen receptor
Used for hormone therapy in ER-positive breast cancer, or as adjuvant therapy following primary breast tumor excision–prevention of breast cancer in high-risk patients?
Tamoxifen
What are the side effects of Tamoxifen?
Hot flushes
Hair loss
N/V
Patients who are put on Tamoxifen are at an increased risk of developing what?
Endometrial cancer
thromboembolic event
Name the selective estrogen receptor down regulator used for hormone therapy…
Fulvestrant
What is the mechanism of action for Fulvestrant?
Binds with much higher affinity to estrogen receptor than tamoxifen–inhibits dimerization which increases degradation and reduces the overall ER level
Used in postmenopausal women with ER-positive metastatic breast cancer…
Fulvestrant
Name the 4 Aromatase inhibitors used for hormone therapy…
Aminoglutethamide
Anastrozole
Letrozole
Exemestane
A relatively weak hormone therapy arrogates inhibitor used for breast cancer treatment…
Aminoglutethamide
First-line for ER-positive breast cancer in postmenopausal women…
Anastrozole
Letrozole and Exemestane are arrogates inhibitors used in hormone therapy. What are they used to treat?
ER-postive breast cancer in postmenopausal women
Name the two GnRH analogs used for Hormone therapy…
Leuprolide
Goserelin
What is the mechanism of action for the GnRH analogs Leuprolide and Goserelin used in hormone therapy?
Binds GnRH receptor–inhibits release of FSH and LH
Leuprolide and Goserelin, GnRH analogs used in hormone therapy, are used to treat what?
Androgen ablation therapy, along with AR blockers
Name the non steroidal androgen-receptor blockers used for hormone therapy…
Flutamide
Bicalutamide
What is the mechanism of action for Fluamide and Bicalutamide?
Competes with androgen for AR binding
What is Flutamide and Bicalutamide, non steroidal androgen-receptor blockers used for?
Androgen ablation therapy, along with GnRH analogs
