Cancer specific chemo treatment Flashcards

1
Q

Hodgkin’s Lymphoma

A
Prednisone--> MOPP and CHOP
Mechlorethamine--> nitrogen mustard
Dacarbazine--> Trazene
Vinblastine (ABVD)--> microtubule inhibitor
Vincristine--> microtubule inhibitor
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2
Q

T-cell lymphoma

A

Mechlorethamine–> nitrogen mustard

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3
Q

Chronic lymphocytic leukemia

A

Cyclophosphamide–> nitrogen mustard

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4
Q

Non-Hodgkin’s lymphoma

A
Prednisone--> MOPP and CHOP
Cyclophosphamide--> nitrogen mustard
Vincristine--> microtubule inhibitor
Etoposide--> Topo II inhibitor
Rituximab--> CD20 B-cell antigen monoclonal antibody
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5
Q

Breast cancer

A

Paclitaxel and Docetaxel–> taxanes–microtubule inhbitors
Cyclophosphamide–> nitrogen mustard
Methotrexate–> folate analog
5 FU–> pyrimidine analong
Capecitabine (oral 5 FU)–> pyrimidine analog
Doxorubicin –> DNA intercalating agent- anthracycline
Epirubicin–> DNA intercalating agent–Anthracycline
Tamoxifen–> SERM–ER + or adjuvant therapy after tumor excision or prevention with FHx
Fulvestrant–> SERD–postmenopausal ER + metastatic breast cx
AIs–> anastrozole (non-steroidal), Letrozole (non-steroidal), exemestane (steroidal)—-1st therapy for ER+ breast cx in postmenopausal women
Trastuzumab–> monoclonal antibody against HER2/neu—HER2/neu-overexpressing metastatic breast cx
Ado-trastuzumab emtanisine

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6
Q

Lung cancer

A

Gemcitabine–> pyrimidine analog

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7
Q

Gastric and colorectal cancer

A

Oxaliplatin–> platinum analog
5-FU–> pyrimidine analog
Epirubicin–> DNA intercalating agent–anthracyclines
Irinotecan–> topo I inhibitor
Cetuximab–> monoclonal antibody against EGFR1–1st line of treatment K Ras wild type EGFR—combination therapy–irinotecan/5FU/Leucovorin
Panitumumab–monoclonal antibody (EGFR-expressing)
Trastuzumab–> gastroesphageal junction carcinoma treatment

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8
Q

Childhood lymphoblastic leukemia (ALL)

A
Prednisone
Methotrexate--> folate analog
Cyarabine--> pyrimidine analog
6-Mercaptopurine--> purine analog--maintains remission
Teniposide--> topo II inhibitor
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9
Q

Choriocarcinoma

A

Methotrexate–> folate analog

Dactinomycin–> DNA intercalating agent (advanced)

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10
Q

Burkitts lymphoma

A

Methotrexate–> folate analog

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11
Q

Head and neck cancers

A

Methotrexate–> folate analog
5FU–> pyrimidine analog
Gemcitabine–> pyrimidine analog
Paclitaxel and docetaxel–> taxanes–microtubule inhibitors
Cetuximab–> anti-ErbB1 -(EGFR) monoclonal antibody

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12
Q

Meningeal leukemia

A

Methotrexate–> folate analog

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13
Q

Meningeal metastases

A

Methotrexate–> folate analog

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14
Q

Osteosarcoma

A

Methotrexate–> folate analog

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15
Q

Colon cancer

A

Pemetrexed–> folate analog

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16
Q

Mesothelioma

A

Pemetrexed–> folate analog

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17
Q

Non-small cell lung cancer

A

Pemetrexed–> folate analog
Gemcitabine–> pyrimidine analog
Gefitinib and Erlotinib–> tyrosine kinase inhibitors–exon 19/21 mutation (also afatinib and lapatinib)

18
Q

Pancreatic cancer

A

Pemetrexed–> folate analog
5FU–> pyrimidine analog
Gemcitabine–> pyrimidine analog (1st line of therapy)

19
Q

Cervical cancer

A

5FU–> pyrimidine analog

irinotecan–> topo I inhibitor

20
Q

Acute myeliod leukemia (AML)

A

Cytarabine–> pyrimidine analog
Daunorubicin–> DNA intercalating agent–anthracycline
Idarubicin–> DNA intercalating agent–anthracycline

21
Q

Chronic myelogenous leukemia (CML)

A

Cytarabine–> pryrimidine analog (blast phase)
Interferons
Imatinib–> 1st line of therapy–tyrosine kinase inhibitor
New generation of tyrosine kinase inhibitors
-Nilotinib
-Dasatinib
-Bosutinib
-Ponatinib

22
Q

Esophageal cancer

A

Gemcitabine–> pyrimidine analog

23
Q

Wilm’s tumor

A

Dactinomycin–> DNA intercalating agent

24
Q

Rhabdomyosarcoma

A

Dactinomycin–> DNA intercalating agent

25
Ewing's sarcoma
Dactinomycin--> DNA intercalating agent
26
Malignant lymphomas
Doxorubicin--> DNA intercalating agent--anthracycline | Bleomycin--> DNA intercalating agent
27
Squamous cell carcinoma
Bleomycin--> DNA intercalating agent
28
Hormone-Refractory prostate cancer
Docetaxel--> taxane microtubule inhibitor
29
Small cell lung cancer
Topotecan--> topo I inhibitor
30
Chronic lymphocytic leukemia (CLL)
Prednisone--> MOPP and CHOP
31
Multiple myeloma
Prednisone--> MOPP and CHOP | Thalidomide
32
Prostate cancer
Leuprolide and Goserelin--> GnRH analogs | Flutamide and Bicalutamide--> Nonsteroidal androgen receptor blockers
33
Polycythemia vera (PV)
Hydroxyurra--> ribonucleotide reductase inhibitor
34
Essential thrombocythemia (ET)
Hydroxyurea--> ribonucleotide reductase inhibitor
35
Sickle cell dz
Hydroxyurea--> ribonucleotide reducetase inhibitor
36
Acute promyelocytic leukemia (APL)
Retinoids--> all-trans retinoid acid | Arsenic trioxide--> heavy metal toxin
37
Myelodysplastic syndromes
Thalidomide
38
Hairy cell leukemia
Interferons
39
AIDS-related Karposi's sarcoma
Interferons
40
GI tumors (GIST)
Imatinib--> tyrosine kinase inhibitor