Cancer specific chemo treatment

Question 1

Hodgkin’s Lymphoma

Answer 1

Prednisone--> MOPP and CHOP
Mechlorethamine--> nitrogen mustard
Dacarbazine--> Trazene
Vinblastine (ABVD)--> microtubule inhibitor
Vincristine--> microtubule inhibitor

Question 2

T-cell lymphoma

Answer 2

Mechlorethamine–> nitrogen mustard

Question 3

Chronic lymphocytic leukemia

Answer 3

Cyclophosphamide–> nitrogen mustard

Question 4

Non-Hodgkin’s lymphoma

Answer 4

Prednisone--> MOPP and CHOP
Cyclophosphamide--> nitrogen mustard
Vincristine--> microtubule inhibitor
Etoposide--> Topo II inhibitor
Rituximab--> CD20 B-cell antigen monoclonal antibody

Question 5

Breast cancer

Answer 5

Paclitaxel and Docetaxel–> taxanes–microtubule inhbitors
Cyclophosphamide–> nitrogen mustard
Methotrexate–> folate analog
5 FU–> pyrimidine analong
Capecitabine (oral 5 FU)–> pyrimidine analog
Doxorubicin –> DNA intercalating agent- anthracycline
Epirubicin–> DNA intercalating agent–Anthracycline
Tamoxifen–> SERM–ER + or adjuvant therapy after tumor excision or prevention with FHx
Fulvestrant–> SERD–postmenopausal ER + metastatic breast cx
AIs–> anastrozole (non-steroidal), Letrozole (non-steroidal), exemestane (steroidal)—-1st therapy for ER+ breast cx in postmenopausal women
Trastuzumab–> monoclonal antibody against HER2/neu—HER2/neu-overexpressing metastatic breast cx
Ado-trastuzumab emtanisine

Question 6

Lung cancer

Answer 6

Gemcitabine–> pyrimidine analog

Question 7

Gastric and colorectal cancer

Answer 7

Oxaliplatin–> platinum analog
5-FU–> pyrimidine analog
Epirubicin–> DNA intercalating agent–anthracyclines
Irinotecan–> topo I inhibitor
Cetuximab–> monoclonal antibody against EGFR1–1st line of treatment K Ras wild type EGFR—combination therapy–irinotecan/5FU/Leucovorin
Panitumumab–monoclonal antibody (EGFR-expressing)
Trastuzumab–> gastroesphageal junction carcinoma treatment

Question 8

Childhood lymphoblastic leukemia (ALL)

Answer 8

Prednisone
Methotrexate--> folate analog
Cyarabine--> pyrimidine analog
6-Mercaptopurine--> purine analog--maintains remission
Teniposide--> topo II inhibitor

Question 9

Choriocarcinoma

Answer 9

Methotrexate–> folate analog

Dactinomycin–> DNA intercalating agent (advanced)

Question 10

Burkitts lymphoma

Answer 10

Methotrexate–> folate analog

Question 11

Head and neck cancers

Answer 11

Methotrexate–> folate analog
5FU–> pyrimidine analog
Gemcitabine–> pyrimidine analog
Paclitaxel and docetaxel–> taxanes–microtubule inhibitors
Cetuximab–> anti-ErbB1 -(EGFR) monoclonal antibody

Question 12

Meningeal leukemia

Answer 12

Methotrexate–> folate analog

Question 13

Meningeal metastases

Answer 13

Methotrexate–> folate analog

Question 14

Osteosarcoma

Answer 14

Methotrexate–> folate analog

Question 15

Colon cancer

Answer 15

Pemetrexed–> folate analog

Question 16

Mesothelioma

Answer 16

Pemetrexed–> folate analog

Question 17

Non-small cell lung cancer

Answer 17

Pemetrexed–> folate analog
Gemcitabine–> pyrimidine analog
Gefitinib and Erlotinib–> tyrosine kinase inhibitors–exon 19/21 mutation (also afatinib and lapatinib)

Question 18

Pancreatic cancer

Answer 18

Pemetrexed–> folate analog
5FU–> pyrimidine analog
Gemcitabine–> pyrimidine analog (1st line of therapy)

Question 19

Cervical cancer

Answer 19

5FU–> pyrimidine analog

irinotecan–> topo I inhibitor

Question 20

Acute myeliod leukemia (AML)

Answer 20

Cytarabine–> pyrimidine analog
Daunorubicin–> DNA intercalating agent–anthracycline
Idarubicin–> DNA intercalating agent–anthracycline

Question 21

Chronic myelogenous leukemia (CML)

Answer 21

Cytarabine–> pryrimidine analog (blast phase)
Interferons
Imatinib–> 1st line of therapy–tyrosine kinase inhibitor
New generation of tyrosine kinase inhibitors
-Nilotinib
-Dasatinib
-Bosutinib
-Ponatinib

Question 22

Esophageal cancer

Answer 22

Gemcitabine–> pyrimidine analog

Question 23

Wilm’s tumor

Answer 23

Dactinomycin–> DNA intercalating agent

Question 24

Rhabdomyosarcoma

Answer 24

Dactinomycin–> DNA intercalating agent

Question 25

Ewing’s sarcoma

Answer 25

Dactinomycin–> DNA intercalating agent

Question 26

Malignant lymphomas

Answer 26

Doxorubicin–> DNA intercalating agent–anthracycline

Bleomycin–> DNA intercalating agent

Question 27

Squamous cell carcinoma

Answer 27

Bleomycin–> DNA intercalating agent

Question 28

Hormone-Refractory prostate cancer

Answer 28

Docetaxel–> taxane microtubule inhibitor

Question 29

Small cell lung cancer

Answer 29

Topotecan–> topo I inhibitor

Question 30

Chronic lymphocytic leukemia (CLL)

Answer 30

Prednisone–> MOPP and CHOP

Question 31

Multiple myeloma

Answer 31

Prednisone–> MOPP and CHOP

Thalidomide

Question 32

Prostate cancer

Answer 32

Leuprolide and Goserelin–> GnRH analogs

Flutamide and Bicalutamide–> Nonsteroidal androgen receptor blockers

Question 33

Polycythemia vera (PV)

Answer 33

Hydroxyurra–> ribonucleotide reductase inhibitor

Question 34

Essential thrombocythemia (ET)

Answer 34

Hydroxyurea–> ribonucleotide reductase inhibitor

Question 35

Sickle cell dz

Answer 35

Hydroxyurea–> ribonucleotide reducetase inhibitor

Question 36

Acute promyelocytic leukemia (APL)

Answer 36

Retinoids–> all-trans retinoid acid

Arsenic trioxide–> heavy metal toxin

Question 37

Myelodysplastic syndromes

Answer 37

Thalidomide

Question 38

Hairy cell leukemia

Answer 38

Interferons

Question 39

AIDS-related Karposi’s sarcoma

Answer 39

Interferons

Question 40

GI tumors (GIST)

Answer 40

Imatinib–> tyrosine kinase inhibitor