Rheumatoid Arthritis and Gout Drugs list

Question 1

Name the non-selective NSAIDs…

Answer 1

Indomethacin

Naproxen

Question 2

Name the selective NSAIDs…

Answer 2

COX-2 inhibitors

Question 3

What are the therapeutic uses of Indomethacin and Naproxen?

Answer 3

Rheumatoid arthritis and acute gouty arthritis

Question 4

What are the therapeutic uses of COX-2 inhibitors?

Answer 4

Superseding conventional NSAIDs for rheumatoid arthritis

Question 5

What are the 2 mechanisms of action for Indomethacin, Naproxen, and COX-2 inhibitors?

Answer 5

Eliminate pain and reduce inflammation

Question 6

What are 2 non-selective NSAIDs and one selective NSAID used for the elimination and pain and reduction of inflammation?

Answer 6

Indomethacin and Naproxen are non-selective

COX-2 inhibitors are selective

Question 7

Name the two main side effects seen from indomethacin and Naproxen… What alternative drug can be used to reduce these side effects?

Answer 7

Gastric and duodenal ulcers

COX-2 inhibitor– 50% fewer gastric and duodenal ulcers than traditional NSAIDs

Question 8

Name the 5 Disease-modifying antirheumatic drugs (DMARDs)?

Answer 8

Quinolones
Glucocorticoids
Sulfasalazine
Methotrexate
Leflunomide

Question 9

Which of the Disease-modifying antirheumatic drugs (DMARDs) is used for both rheumatoid arthritis and SLE?

Answer 9

Quinolones

Question 10

Which of the Disease-modifying antirheumatic drugs (DMARDs) is used for both rheumatoid arthritis and acute gouty arthritis?

Answer 10

Glucocorticoids

Question 11

What is the major side effect of Quinolones?

Answer 11

Retinal damage

Question 12

When patients no longer respond to NSAIDs or can’t tolerate other Disease-modifying antirheumatic drugs (DMARDs), which Disease-modifying antirheumatic drugs (DMARDs) is indicated?

Answer 12

Quinolones

Question 13

What is the mechanism for Quinolones?

Answer 13

Reduces T-cell activation and chemotaxis

Question 14

Which Disease-modifying antirheumatic drugs (DMARDs) inhibit phospholipase A2–inhibiting the formation of prostaglandins and also inhibits cytokine production preventing induction of COX-2?

Answer 14

Glucocorticoids

Question 15

What Disease-modifying antirheumatic drugs (DMARDs) inhibits the release of IL-1 and TNF-a?

Answer 15

Sulfasalazine

Question 16

Which Disease-modifying antirheumatic drugs (DMARDs) inhibits aminoimidazolecarboxamide transformylase and thymidylate synthetase and also causes adenosine accumulation inhibiting inflammation?

Answer 16

Methotrexate

Question 17

Which Disease-modifying antirheumatic drugs (DMARDs) inhibits dihydroorotate dehydrogenase, which inhibits T-lympocyte response to stimuli?

Answer 17

Leflunomide

Question 18

Name the major side effects of Glucocorticoids…

Answer 18

Cushingoid symptoms

Question 19

What are the major side effects of Sulfasalazine?

Answer 19

N/V, skin rashes, neutropenia

Headaches can also occur

Question 20

What are the major side effects of Methotrexate?

Answer 20

Nausea, stomatitis, hepatotoxicity

Question 21

What are the major side effects of Leflunomide?

Answer 21

Diarrhea, hepatotoxicity

Question 22

Which Disease-modifying antirheumatic drugs (DMARDs) is considered the gold standard of therapy for Rheumatoid arthritis?

Answer 22

Methotrexate

Question 23

Name the 10 biologic response modifiers used to treat Rheumatoid arthritis…

Answer 23

Etanercept
Infliximab
Adalimumab
Golimumab
Certolizumab
Anakinra
Tocilizumab
Rituximab
Abatacept
Tofacitinib

Question 24

Name the 5 Biologic response modifiers that block binding of TNF to TNF receptors to help treat Rheumatoid arthritis…

Answer 24

Etanercept
Infliximab
Adalimumab
Golimumab
Certolizumab

Question 25

What is the mechanism of action for Anakinra, used in the treatment of Rheumatoid arthritis?

Answer 25

IL-1 receptor antagonist

Question 26

What is the mechanism of action for Tocilizumab, used in the treatment of Rheumatoid arthritis?

Answer 26

IL-6 Receptor antagonist

Question 27

Which biologic response modifier used to treat rheumatoid arthritis is anti-CD20 mAB reducing the number of circulating B cells?

Answer 27

Rituximab

Question 28

Which biologic response modifier used to treat rheumatoid arthritis inhibits T-cell activation and induces T-cell apoptosis?

Answer 28

Abatacept

Question 29

Which biologic response modifier used to treat rheumatoid arthritis inhibits JAK 1 & 3 inhibiting production of inflammatory mediators?

Answer 29

Tofacitinib

Question 30

What are the side effects seen with Infliximab?

Answer 30

Antigenic response to murine monoclonal Ab

Question 31

What are the side effects seen with Golimumab?

Answer 31

Risk of serious infections

Question 32

What are the side effects seen with Certolizumab?

Answer 32

Risk of serious infections

Question 33

What are the side effects seen with Rituximab?

Answer 33

Infections | Hypersensitivity reactions

Question 34

What are the side effects seen with Adatacept?

Answer 34

Headaches | Infections

Question 35

Where are the side effects seen with Tofacitinib?

Answer 35

Upper respiratory tract infections Headaches Diarrhea

Question 36

What drug is used to treat acute gouty arthritis, works within 12-24 hours and prevents tubular polymerization leading to inhibition of leukocyte migration, phagocytosis, and release of cytokines?

Answer 36

Colchicine

Question 37

What are the side effects of long-term use of Colchicine?

Answer 37

peripheral neuropathy and neutropenia Also can cause N/V, abdominal pain, diarrhea

Question 38

What uricosuric agent is used in the treatment of chronic tophaceous gout?

Answer 38

Probenecid

Question 39

Which drug used in the treatment of chronic tophaceous gout competes with rate at the anionic transport site od the renal tubule and inhibits rate reabsorption?

Answer 39

Probenecid

Question 40

What are the side effects seen with Probenecid?

Answer 40

Urate crystal mobilization and acute gouty arthritis Also can cause GI irritation

Question 41

What drug reduces uric acid synthesis by inhibiting xanthine oxidase to alloxanthine in treatment of Chronic tophaceous gout?

Answer 41

Allopurinol

Question 42

What are the side effects seen with Allopurinol?

Answer 42

Acute attacks of gouty arthritis early in treatment due to mobilization of rate crystals

Question 43

What drug is a non-purine, non-competitive antagonist of xanthine oxidase used in the treatment of chronic tophaceous gout?

Answer 43

Febuxostat

Question 44

What are the side effects seen with Febuxostat?

Answer 44

Nausea Rash Arthralgias

Question 45

A recombinant stabilized fricassee used to convert uric acid to allantoin used in the treatment of chronic tophaceous gout is?

Answer 45

Pegloticase