CYP enzymes Flashcards
What is a prodrug?
medication that is administered in an inactive or less than fully active form
Converted to its active form through a normal metabolic process
What is induction?
Biotransformation by induced CYP enzymes
Results in either
increased activity of a prodrug
or
Enhanced elimination of drugs
What is inhibition?
Results in
Increased bioavailability of a drug
Or
Decreased activity of a prodrug
Name the drugs that are metabolized by 1A2…
Caffeine
Theophylline
Name the inhibitors of 1A2…
Grapefruit juice
Name the inducers of 1A2…
Smoking
Charred food
Name the drugs that are metabolized by 2C9…
Phenytoin
Warfarin
Name the inhibitors of 2C9…
Macrolides
Name the inducers of 2C9…
Rifampicin
Name the drugs that are metabolized by 2C19…
Diazepam
Name the inhibitors of 2C19…
Fluoxetine
Name the inducers of 2C19…
St. John’s wart
Name the drugs that are metabolized by 2D6…
Codeine
Name the inhibitors of 2D6…
Quinidine
Haloperidol
Name the inducers of 2D6…
St, John’s wart
Rifampin
Name the drugs that are metabolized by 2E1…
Paracetamol
Name the drugs that are metabolized by 3A4…
Terfenadine
Verapamil
Name the inhibitors of 3A4…
Ketoconazole
Itraconazole
Name the inducers of 3A4…
St. John’s wart
2C9 is a _____ and is seen in what 3 ethnic groups?
Poor metabolizer
African americans
Asians
Whites
2C19 is a ______ and is seen in what 3 ethnic groups?
Poor metabolizer
African americans
Asians
Whites
2D6 is a ___ in what ethnic groups and a _____ in what ethnic groups?
Poor metabolizer
African americans
Asians
Whites
Ultra extensive metabolizer
Asians
Ethiopians
Northern and Southern Europeans
