Microtubule Inhibitors Flashcards
Name the two Vinca alkaloid microtubule inhibitors…
Vinblastine
Vincristine
What do the Vinca alkaloid microtubule inhibitors block in order to stop mitosis and cause metaphase arrest?
Block tubulin polymerization into microtubules
What class does Vinblastine and Vincristine fall into?
Vinca alkaloids
Which microtubule inhibitor is used in combination with bleomycin/cisplatin to treat metastatic testicular tumors?
Vinblastine
ABVD is a combination therapy used to treat Hodgkin’s disease. Which drug in this therapy is a microtubule inhibitor?
Vinblastine
What microtubule inhibitor is used to treat childhood ALL in combination with glucocorticoids?
Vincristine
Besides treating childhood ALL, what else does Vincristine, a microtubule inhibitor, treat?
Non-Hodkin’s and Hodgkin’s lymphomas
What are the side effects of Vinblastine?
Myelosuppression
N/V
What are the side effects of Vincristine?
Dose-limiting neurotoxicity–peripheral neuropathy
Low bone marrow toxicity
Name the two Taxane microtubule inhibitors…
Paclitaxel
Docetaxel
What is the mechanism of action for the Taxanes, Paclitaxel and Docetaxel?
Block microtubule depolymerization into tubulin
Paclitaxel and Docetaxel, taxane microtubule inhibitors, are both used for treatment of what cancers? Docetaxel is used for the treatment of one additional cancer, what is it?
Metastatic breast, ovarian, lung, and head and neck cancers
Docetaxel–also used for the treatment of hormone refractory prostate cancer
Paclitaxel and Docetaxel, taxane microtubule inhibitors, have the same side effects, what are they?
Peripheral neuropathy
Neutropenia
Hypersensitivity reactions
