Topic 75 - 80 Flashcards
Which two proteins take part in the cytokine signal transduction besides the receptor?
- JAK
- STAT
Name t wo cytokines!
- Growth hormone
- Prolactine
How do interferons effect virus infection?
Inhibit it
Name the transcription factors that mediate TGF-(beta) simulations!
Smad dimers
What kind of protein is the Hedgehog protein?
Secreted ligand
Name a tumor sepresor protein involved in Wnt signaling!
APC protein
Give an example for juxtacrine signaling!
Notch signaling
Give an example for a cytoplasmic transcription factor translocating to the nucleus upon simulation only!
NFkB
What transcription factor is indirectly activated by IkB kinase?
NFkB
Name a tyrosine protein kinese present in focal adhesions!
FAK (fuck)
Name three transcription factors which can br endpoints of signal transduction pathways!
- AP-1
- CREB
- STAT
Which signal transduction pathway is affected in nephrogenic diabetes insipidus?
cAMP-pathway
What is the effect of cholera towin?
Constituitive activation of Gs proteins
Name three diseases resulting from abnormal function of signal transduction pathways!
- Type II diabetes
- Cholera
- Tumors
How is the NFkB pathway affected in chronic inflammatory diseases?
It is activated