Topic 75 - 80 Flashcards

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0
Q

Which two proteins take part in the cytokine signal transduction besides the receptor?

A
  • JAK

- STAT

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1
Q

Name t wo cytokines!

A
  • Growth hormone

- Prolactine

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2
Q

How do interferons effect virus infection?

A

Inhibit it

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3
Q

Name the transcription factors that mediate TGF-(beta) simulations!

A

Smad dimers

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4
Q

What kind of protein is the Hedgehog protein?

A

Secreted ligand

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5
Q

Name a tumor sepresor protein involved in Wnt signaling!

A

APC protein

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6
Q

Give an example for juxtacrine signaling!

A

Notch signaling

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7
Q

Give an example for a cytoplasmic transcription factor translocating to the nucleus upon simulation only!

A

NFkB

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8
Q

What transcription factor is indirectly activated by IkB kinase?

A

NFkB

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9
Q

Name a tyrosine protein kinese present in focal adhesions!

A

FAK (fuck)

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10
Q

Name three transcription factors which can br endpoints of signal transduction pathways!

A
  • AP-1
  • CREB
  • STAT
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11
Q

Which signal transduction pathway is affected in nephrogenic diabetes insipidus?

A

cAMP-pathway

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12
Q

What is the effect of cholera towin?

A

Constituitive activation of Gs proteins

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13
Q

Name three diseases resulting from abnormal function of signal transduction pathways!

A
  • Type II diabetes
  • Cholera
  • Tumors
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14
Q

How is the NFkB pathway affected in chronic inflammatory diseases?

A

It is activated

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