Topic 74 (Growth Factor Signaling) Flashcards
0
Q
Naime the three domain of growth receptros!
A
- Ligand binding domain
- Transmembrane domain
- Kinase domain
1
Q
Name two growth factors!
A
- EGF
- NGF
2
Q
Name the function of SH2 domain!
A
Recognition and binding of phosphotyrosine
3
Q
Name the function of the SH3 domain!
A
Binding of target proteins
4
Q
Which protein activates RAS? How?
A
GEF, exchanges GDP to GTP
5
Q
Name a mitogen-activated protein kinese!
A
JNK
6
Q
Name the lipid kinase activated in growth factor signaling!
A
PI3K
7
Q
What is the enzyme activity of the PTEN protein?
A
Lipid Phosphatase
8
Q
Name the lipid phosphatase involved in growth factor signaling!
A
PTEN
9
Q
Name a monomeric G protein involved in the regulation of the cytosceleton!
A
Rho
10
Q
What are the 2 mechanisms that are required for the inactivation of the Ras protein?
A
Ras has intrinsic GTPase activity that is increased by GAP
