topic 10 (part 1) Flashcards

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1
Q

7list the stages of the cell cycle

A
  1. G1 phase
  2. S phase
  3. G2 phase
  4. M phase
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2
Q

the cell cycle consists of _____ and _____?

A

interphase and mitosis

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3
Q

what is G0 phase also known as?

A

quiescent phase

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4
Q

what occurs during G0 phase?

A

non-dividing cells enter this phase and rest

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5
Q

cells exit G1 and enter G0 in order to _____

A

differentiate

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6
Q

differentiated cells enter from G0 to G1 after the action of _____?

A

growth factors (mytogens)

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7
Q

what are 3 types of cells differentiated according to their cell division potential?

A
  • post-mitotic cells
  • cells that divide upon appropriate stimulation (signals)
  • cells with high mitotic activity
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8
Q

what are post-mitotic cells?

A

terminally differentiated cells which have lost their ability to replicate (permanently arrested at G0)

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9
Q

what is an example of a post-mitotic cell?

A

neural cells, RBCs, cardiac muscle cells

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10
Q

what is an example of cells that divide upon appropriate stimulation (signals)

A

lymphocytes upon antigenic presentation

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11
Q

what is an example of cells with high mitotic activity?

A

germ cells, stem cells, epithelial cells

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12
Q

what occurs during G1 phase? how long does it last?

A
  • preparation for DNA replication
  • protein synthesis/organelle production
  • 5-6 hrs
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13
Q

what occurs during S phase? how long does it last?

A
  • DNA synthesis
  • 10-12 hrs
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14
Q

what occurs during G2 phase? how long does it last?

A
  • preparation for mitosis
  • (same as G1)
  • 4-6 hrs
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15
Q

what are the 2 types of cells?

A
  • somatic (diploid cells)
  • gametes (haploid)
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16
Q

what are homologous chromosomes?

A

chromosomes that carry the same genes at the same positions

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17
Q

what occurs during interphase?

A
  • chromosomes are not condensed

G1 - each chromosomes consists of one chromatid (not yet replicated)

S - DNA is replicated

G2 - each duplicated chromosome has 2 sister chromatids

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18
Q

what is the difference between sister chromatids and homologous chromosomes?

A

sister chromatids - are genetically identical and used in cell division

homologous chromosomes - composed of two different chromosomes that are not genetically identical despite containing the same sets of genes

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19
Q

what occurs during mitosis (cell division)?

A
  • the chromosomes condense
  • sister chromatids separate (each future daughter cell receives one chromatid)
20
Q

the mitotic phase (M phase) consists of _____ and _____

A
  • mitosis (division of the nucleus)
  • cytokinesis (division of the cytoplasm)
21
Q

mitosis consists of 5 phases

A
  • prophase
  • prometaphase
  • metaphase
  • anaphase
  • telophase
22
Q

prophase

A
  1. chromatin condenses into distinct chromosomes
  2. nucleoli disappear/nuclear membrane degrades
  3. mitotic spindle begins forming (composed of centrosomes & microtubules)
23
Q

prometaphase

A
  1. fragments of the nuclear envelope are seen
  2. microtubules extending from each centrosome can invade the nuclear area and bind to the chromosomes
24
Q

metaphase

A
  1. chromosomes become aligned at the metaphase plate
  2. centrosomes are now at opposite poles
25
Q

anaphase

A
  1. each sister chromatid of a chromosome moves towards opposite poles
  2. by the end, the two poles of the cell have equivalent collections of chromosomes (chromatids)
26
Q

telophase

A
  1. nucleoli reappear/nuclear envelope reforms
  2. chromosomes decondense
  3. two daughter nuclei form
  4. mitosis is complete
27
Q

cytokinesis

A

occurs in animal cells by a process called cleavage, where a cleavage furrow forms, and cells are completely separated

28
Q

mitotic spindle begins to form by

A

polymerization of mictrotubules

29
Q

microtubule polymerization starts from

A

the centrosome

30
Q

kinetochores

A

protein structures found at the centromere of each chromosome

31
Q

_____ attach to the kinetochores of the chromatids to move chromosomes towards the metaphase plate

A

mitotic spindle microtubules

32
Q

kinetochores are also the attachment point for

A

motor proteins

33
Q

3 types of mitotic spindle microtubules

A
  1. astral microtubules
  2. kinetochore microtubules (or chromosomal)
  3. polar microtubules
34
Q

astral microtubules

A
  • radial (star-like) structure around the centrosome
  • helps in positioning of the spindle in the cell
35
Q

kinetochore microtubules

A
  • join the centrosome with the kinetochores of the chromosomes
  • helps in chromosomal movement
36
Q

polar microtubules

A
  • start from the centrosome but do not attach to the chromosomes
  • interact with other polar microtubules projecting from the other pole
  • help maintain the integrity of the spindle
37
Q

nuclear lamin

A

intermediate filaments present in the nuclear lamina

38
Q

nuclear lamin phosphorylation

A

nuclear envelope degradation and packaging into vesicles

39
Q

begins upon degradation of nuclear envelope

A

prometaphase

40
Q

in prometaphase chromosomes move towards the cell center (metaphase plate) by

A

polymerization/depolymerization of kinetochore microtubules

41
Q

if chromosomes are not aligned correctly in metaphase

A

cell cycle arrest signal is activated

42
Q

endoplasmic reticulum and golgi apparatus are degraded and packaged into vesicles during _____ and reformed during _____

A

prophase, telophase

43
Q

prokaryotes reproduce by

A

binary fission

44
Q

compared to eukaryotic cell cycle, binary fission is

A

much faster and more simple (1-3 hrs)

45
Q

binary fission being much quicker is important to

A

allow rapid evolution of bacteria

46
Q

multiple fission

A

some unicellular eukaryotes exhibit types of cell division intermediate between mitosis and binary fission that is usually followed by multiple cytokinesis