tooth development Flashcards
Ectoderm lining stomodeum gives rise to oral epithelium
on the
1st branchial arch.
when is primary epithelial band formed
6th week of prenatal development
Primary epithelial band origin
oral epithelium
thickens and invaginate into the ectomesenchyme
Primary epithelial band
These bands are roughly
horseshoe shaped and
correspond to the future dental
arches of the upper & lower jaws
what happen by the 7th week
primary epithelial band
will divide to form:
(1) vestibular lamina
(2) dental lamina
Vestibular lamina
form vestibule
Vestibular lamina process
Cells of the vestibular lamina will proliferate,
and then the central epithelial cells
degenerate to form the sulcus of the vestibule
between the cheek and the tooth bearing
area.
Dental lamina
-Dental lamina contributes to the development of teeth.
• Dental lamina is not a strand but a sheet.
• Is divided into General lamina & Lateral lamina
dentall lamina process
Within the dental lamina continued & localized proliferative
activity leads to the formation of a series of epithelial
outgrowths into the ectomesenchyme,
the outgrowth occurs at sites corresponding to future deciduous teeth
What controls the initiation of tooth
development?
earliest msenchymal markers = Lhx 6 & 7 (expressed at ncc)
lhx induced by fgf8
fgf expressed at 1st branchial arch
What controls the position & number of tooth
germs?
pax 9 - define location of tooth germs
fgf8 induce pax 9
TOOTH TYPE DETERMINATION
PATTERNING , homodont and heterodont
Hypothetical Models Explaining How Different
Tooth Shapes Are Determined
field model and clone model
field model
Genes responsible for tooth shape reside within the ectomesenchyme in distinct BUT graded fields for each tooth family. Each of the fields express differing patterning homeobox genes. However, genes in the oral epithelium provides the signalling.
clone model
Each tooth class is derived from a clone of
ectomesenchymal cells programmes by
epithelium to produce tooth of a given pattern.
A: The molar clone has induced the dental lamina to begin tooth development. At its
posterior border the clone and dental lamina grow posteriorly by means of the
progress zone.
B: When a clone reaches the critical size, a tooth bud is initiated at its center.
C: The next tooth bud is initiated until the progress zone of the clone has escaped
its influence
when is bud stage
8th week of prenatal development
what happen during bud stage
A series of epithelial outgrowth develops on the surface of the dental lamina.. Forming tooth bud maxillary arch : 10 buds mandibular arch : 10 buds
when is early cap stage
Forming tooth bud
maxillary arch : 10 buds
mandibular arch : 10 buds
what happen during early cap stage (1)
Each of the tooth buds
Will invaginate into the
ectomesenchyme to form a capshaped structure.
tooth germ
what happen during early cap stage (2)
Nerve fibres & blood vessels are NOT present
in the enamel organ at any time.
• Blood vessels enters the dental papilla during
cap stage.
• Blood vessels are also found around the tooth
germ in the dental follicle
tooth germ
enamel organ, dental papilla, dental follicle
late cap stage
histodifferentiation Epithelial cells in the enamel organ will differentiate to form Stellate reticulum (SR) during late cap stage. However, the development of SR will continues until early bell stage formation of transitory structures. formation of permanent dentition
stellate reticulum
Cells in the center of the enamel organ synthesize &
secrete glycosaminoglycans into the extracellular
components between the epithelial cells
Glycosaminoglycans are hydrophilic, and so pull
water into the enamel organ
Volume of the extracellular compartment of the enamel
organ increases, forcing the central cells to separate.
The cells retained connections through desmosomal
contacts, and thus become star shape & is termed
Stellate Reticulum (SR)
TRANSITORY STRUCTURES
- Enamel knot
- Enamel cord
- Enamel niche
- Enamel navel