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Immunology - Unit 1 - Zach H. > Toll-like Receptors, TLRs - Innate Immunity > Flashcards

Toll-like Receptors, TLRs - Innate Immunity Flashcards

1
Q

TLRs on cell surface that recognize extracellular pathogens?

A

TLR 1, 2, 4, 5, and 6

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2
Q

What do endosomal TLRs only respond to?

A

nucleic acids

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3
Q

TLRs that recognize only intracellular pathogens?

A

TLR-3, 7, 8, and 9

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4
Q

TLR for peptidoglycan

A

TLR-2

gram-positive bacteria

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5
Q

TLR for LPS

A

TLR-4

gram-negative bacteria

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6
Q

TLR for other microbe classes?

A

TLRX

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7
Q

TLR1:TLR2 heterodimer

A

ligands:
> lipopeptides
> GPI

cell carrying receptor:
> monocytes 
> DCs
> eosinophils 
> basophils 
> mast cells

cellular location of receptor:
> plasma membrane

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8
Q

TLR2:TLR6 heterodimer

A

ligands:
> lipoteichoic acid
> zymosan

cells carrying receptor:
> monocytes
> DCs
> eosinophils
> basophils
> mast cells

cellular location of receptor:
> plasma membrane

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9
Q

TLR3

A

ligands:
> ds viral RNA

cells carrying receptor:
> NK cells

location of receptor:
> endosomes

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10
Q

TLR4: TLR4 homodimer

A

ligands:
> LPS

cells carrying receptor:
> macrophages 
> DCs
> mast cells
> eosinophils

location of receptor:
> plasma membrane

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11
Q

TLR5

A

ligands:
> flagellin

cells carrying receptor:
> intestinal epithelium

location of receptor:
> plasma membrane

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12
Q

TLR7

A

ligands:
> ss viral RNAs

cells carrying receptor:
> plasmacytoid DCs
> NK cells 
> eosinophils
> B cells

location of receptor:
> endosomes

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13
Q

TLR8

A

ligands:
> ss viral RNAs

cells carrying receptor:
> NK cells

location of receptor:
> endosomes

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14
Q

TLR9

A

ligands:
> unmethylated CpG-rich DNA

cells carrying receptor:
> plasmacytoid dendritic cells
> B cells 
> eosinophils 
> basophils

location of receptor:
> endosomes

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15
Q

TLR10 homodimer and heterodimers with TLR1 and 2.

A

ligands:
> unknown

cells carrying receptor:
> plasmacytoid DCs 
> basophils 
> eosinophils
> B cells

location of receptor:
> unknown

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16
Q

TLRs 1, 2, 5, and 6 us what adapter protein to activate NF-kB?

A

MyD88

17
Q

TLR3 uses what adaptor protein to activate IRF transcription factors?

A

TRIF

18
Q

TLR4

A

activates IRF and MyD88

19
Q

TLRs 7 and 9 in endosome use MyD88 to activate?

A

Both NF-kB and IRF

20
Q

What cells in innate immunity express TLRs?

A
  • monocytes
  • neutrophils
  • macrophages
  • DCs
21
Q

What does IL-12 do?

A

controls adaptive T-cell immune response

Immunology - Unit 1 - Zach H. (12 decks)

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